Factors Affecting Phage–Bacteria Coevolution Dynamics
Bacteriophages (phages) have coevolved with their bacterial hosts for billions of years. With the rise of antibiotic resistance, the significance of using phages in therapy is increasing. Investigating the dynamics of phage evolution can provide valuable insights for pre-adapting phages to more chal...
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MDPI AG
2025-02-01
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| author | Ghadeer Jdeed Bogdana Kravchuk Nina V. Tikunova |
| author_facet | Ghadeer Jdeed Bogdana Kravchuk Nina V. Tikunova |
| author_sort | Ghadeer Jdeed |
| collection | DOAJ |
| description | Bacteriophages (phages) have coevolved with their bacterial hosts for billions of years. With the rise of antibiotic resistance, the significance of using phages in therapy is increasing. Investigating the dynamics of phage evolution can provide valuable insights for pre-adapting phages to more challenging clones of their hosts that may arise during treatment. Two primary models describe interactions in phage–bacteria systems: arms race dynamics and fluctuating selection dynamics. Numerous factors influence which dynamics dominate the interactions between a phage and its host. These dynamics, in turn, affect the coexistence of phages and bacteria, ultimately determining which organism will adapt more effectively to the other, and whether a stable state will be reached. In this review, we summarize key findings from research on phage–bacteria coevolution, focusing on the different concepts that can describe these interactions, the factors that may contribute to the prevalence of one model over others, and the effects of various dynamics on both phages and bacteria. |
| format | Article |
| id | doaj-art-901ded04235048aca25b20a2be30e8e6 |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-901ded04235048aca25b20a2be30e8e62025-08-20T02:45:42ZengMDPI AGViruses1999-49152025-02-0117223510.3390/v17020235Factors Affecting Phage–Bacteria Coevolution DynamicsGhadeer Jdeed0Bogdana Kravchuk1Nina V. Tikunova2Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Prospect Lavrentieva 8, Novosibirsk 630090, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Prospect Lavrentieva 8, Novosibirsk 630090, RussiaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Prospect Lavrentieva 8, Novosibirsk 630090, RussiaBacteriophages (phages) have coevolved with their bacterial hosts for billions of years. With the rise of antibiotic resistance, the significance of using phages in therapy is increasing. Investigating the dynamics of phage evolution can provide valuable insights for pre-adapting phages to more challenging clones of their hosts that may arise during treatment. Two primary models describe interactions in phage–bacteria systems: arms race dynamics and fluctuating selection dynamics. Numerous factors influence which dynamics dominate the interactions between a phage and its host. These dynamics, in turn, affect the coexistence of phages and bacteria, ultimately determining which organism will adapt more effectively to the other, and whether a stable state will be reached. In this review, we summarize key findings from research on phage–bacteria coevolution, focusing on the different concepts that can describe these interactions, the factors that may contribute to the prevalence of one model over others, and the effects of various dynamics on both phages and bacteria.https://www.mdpi.com/1999-4915/17/2/235coevolutionphage therapyarms race dynamicsfluctuating selection dynamicsphage adaptationhost range expansion |
| spellingShingle | Ghadeer Jdeed Bogdana Kravchuk Nina V. Tikunova Factors Affecting Phage–Bacteria Coevolution Dynamics Viruses coevolution phage therapy arms race dynamics fluctuating selection dynamics phage adaptation host range expansion |
| title | Factors Affecting Phage–Bacteria Coevolution Dynamics |
| title_full | Factors Affecting Phage–Bacteria Coevolution Dynamics |
| title_fullStr | Factors Affecting Phage–Bacteria Coevolution Dynamics |
| title_full_unstemmed | Factors Affecting Phage–Bacteria Coevolution Dynamics |
| title_short | Factors Affecting Phage–Bacteria Coevolution Dynamics |
| title_sort | factors affecting phage bacteria coevolution dynamics |
| topic | coevolution phage therapy arms race dynamics fluctuating selection dynamics phage adaptation host range expansion |
| url | https://www.mdpi.com/1999-4915/17/2/235 |
| work_keys_str_mv | AT ghadeerjdeed factorsaffectingphagebacteriacoevolutiondynamics AT bogdanakravchuk factorsaffectingphagebacteriacoevolutiondynamics AT ninavtikunova factorsaffectingphagebacteriacoevolutiondynamics |