Hyaluronic acid-tailored prodrug nanoplatforms for efficiently overcoming colorectal cancer chemoresistance and recurrence by synergistic inhibition of cancer cell stemness

Hyaluronic acid-tailored prodrug nanoplatforms for efficiently overcoming colorectal cancer chemoresistance and recurrence by synergistic inhibition of cancer cell stemness

Abstract A subset of residual colorectal cancer (CRC) cells with stemness features exhibits a transient adaptive resistance after chemotherapy, limiting durable therapeutic benefits and even accelerating tumor recurrence. To tackle this problem, we have developed a targeted polymer prodrug nanoplatf...

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Bibliographic Details
Main Authors: Xirui Duan, Hailong Tian, Peilan Peng, Ping Zhou, Ning Ding, Guowen Liu, Gary T. Bentley, Canhua Huang, Jun Yang, Ke Xie
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Colorectal cancer
Chemoresistance
Recurrence
Site-specific polymer prodrug
Stem maintenance
Online Access:https://doi.org/10.1186/s12951-025-03484-x
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