Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention
Bone remodeling is a complex process that includes two mutually coordinated phases of bone resorption and bone formation, which plays an important role in preventing bone aging and increasing bone density. In recent years, studies have shown that mitochondrial autophagy (mitophagy) plays an importan...
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| Format: | Article |
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Editorial Office of Journal of Guangxi Medical University
2024-11-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.006 |
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| _version_ | 1850190167125524480 |
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| author | WANG Yiyuan LIU Siyi JIANG Honghui PU Wen LIU Canyan XU Jiake |
| author_facet | WANG Yiyuan LIU Siyi JIANG Honghui PU Wen LIU Canyan XU Jiake |
| author_sort | WANG Yiyuan |
| collection | DOAJ |
| description | Bone remodeling is a complex process that includes two mutually coordinated phases of bone resorption and bone formation, which plays an important role in preventing bone aging and increasing bone density. In recent years, studies have shown that mitochondrial autophagy (mitophagy) plays an important regulatory role in the process of bone resorption and bone formation. Mitochondrial autophagy is a special cellular clearance process that maintains normal mitochondrial function and metabolism by removing damaged mitochondria. With the in-depth understanding of the regulatory mechanisms of mitophagy, combined with the study of drug interventions, it is expected that more effective treatments will be developed to improve the quality of life of patients with orthopedic-related diseases such as osteoporosis. At the same time, it will also provide new perspectives and strategies for the prevention and treatment of orthopedic-related diseases. |
| format | Article |
| id | doaj-art-9009a48d63ff43fa826bf4909cacbbe4 |
| institution | OA Journals |
| issn | 1005-930X |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-9009a48d63ff43fa826bf4909cacbbe42025-08-20T02:15:23ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-11-0141111483149010.16190/j.cnki.45-1211/r.2024.11.006gxykdxxb-41-11-1483Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug interventionWANG Yiyuan0LIU Siyi1JIANG Honghui2PU Wen3LIU Canyan4XU Jiake5Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, ChinaLife Sciences Institute, Guangxi Medical University, Nanning 530021, ChinaCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, ChinaCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, ChinaCollege of Pharmacy, Guangxi Medical University, Nanning 530021School of Biomedical Sciences, the University of Western Australia, Perth 6009, AustraliaBone remodeling is a complex process that includes two mutually coordinated phases of bone resorption and bone formation, which plays an important role in preventing bone aging and increasing bone density. In recent years, studies have shown that mitochondrial autophagy (mitophagy) plays an important regulatory role in the process of bone resorption and bone formation. Mitochondrial autophagy is a special cellular clearance process that maintains normal mitochondrial function and metabolism by removing damaged mitochondria. With the in-depth understanding of the regulatory mechanisms of mitophagy, combined with the study of drug interventions, it is expected that more effective treatments will be developed to improve the quality of life of patients with orthopedic-related diseases such as osteoporosis. At the same time, it will also provide new perspectives and strategies for the prevention and treatment of orthopedic-related diseases.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.006mitophagybone remodelingpharmacological interventionsorthopedic-related diseases |
| spellingShingle | WANG Yiyuan LIU Siyi JIANG Honghui PU Wen LIU Canyan XU Jiake Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention Guangxi Yike Daxue xuebao mitophagy bone remodeling pharmacological interventions orthopedic-related diseases |
| title | Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention |
| title_full | Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention |
| title_fullStr | Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention |
| title_full_unstemmed | Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention |
| title_short | Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention |
| title_sort | advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention |
| topic | mitophagy bone remodeling pharmacological interventions orthopedic-related diseases |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.006 |
| work_keys_str_mv | AT wangyiyuan advancesinmitochondrialautophagyregulationofboneremodelingandtheroleofdrugintervention AT liusiyi advancesinmitochondrialautophagyregulationofboneremodelingandtheroleofdrugintervention AT jianghonghui advancesinmitochondrialautophagyregulationofboneremodelingandtheroleofdrugintervention AT puwen advancesinmitochondrialautophagyregulationofboneremodelingandtheroleofdrugintervention AT liucanyan advancesinmitochondrialautophagyregulationofboneremodelingandtheroleofdrugintervention AT xujiake advancesinmitochondrialautophagyregulationofboneremodelingandtheroleofdrugintervention |