Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics
Abstract Background Rapid, label-free and depth-resolved imaging of atopic dermatitis (AD) at high resolution has long been a challenge due to current dermoscopes are limited by inadequate resolution, sensitivity and the lack of three-dimensional (3D) imaging capability. Methods Herein, we present p...
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2025-06-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06228-5 |
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| author | Fengxian Du Huiling Wu Junwei Xue Shenglan Yao Ronghui Li Jinde Zhang Haitao Wang Qi Cheng Fan Zhao Ying Huang Zijian Zhou Feng Liang Xiufei Gu Valery V. Tuchin Qingliang Zhao |
| author_facet | Fengxian Du Huiling Wu Junwei Xue Shenglan Yao Ronghui Li Jinde Zhang Haitao Wang Qi Cheng Fan Zhao Ying Huang Zijian Zhou Feng Liang Xiufei Gu Valery V. Tuchin Qingliang Zhao |
| author_sort | Fengxian Du |
| collection | DOAJ |
| description | Abstract Background Rapid, label-free and depth-resolved imaging of atopic dermatitis (AD) at high resolution has long been a challenge due to current dermoscopes are limited by inadequate resolution, sensitivity and the lack of three-dimensional (3D) imaging capability. Methods Herein, we present promising optical coherence tomography (OCT) and OCT angiography (OCTA) collaborative multi-parameter image processing algorithms (OCT/OCTA) that have been developed for long-term, dynamic longitudinal investigation of subtly changes in tissue structure during the dynamic development of AD, especially in the microvascular network. Results The OCT image demonstrated a ‘roller-coaster’ trend in skin thickness throughout the progression of dermatitis, initially exhibiting an increase and subsequently a decrease. Moreover, the OCTA image enabled the discernment of a displacement of the superficial vascular plexus to deeper layers as the severity of AD increased. Furthermore, the results of the quantitative analysis of vascular multiparametric features at different stages, including vessel diameter, length, and density, also demonstrated a positive correlation with the severity of AD. Conclusion Overall, the full-cycle dynamic changes in skin thickness and depth-resolved vascular alterations during the progression of dermatitis can be effectively predicted using OCT/OCTA, which can inform more targeted AD diagnosis and treatment strategies. Furthermore, this method has the potential to assess therapeutic drug efficacy by capturing microvascular and structural responses across different stages of treatment. The presented methods have the potential to provide new insight into the monitoring of long-term vascular and tissue structure responses before and after therapeutic intervention in a range of AD-related skin diseases. |
| format | Article |
| id | doaj-art-90065fc1d1df4e4c9b54e3b019d2bf2d |
| institution | DOAJ |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | Journal of Translational Medicine |
| spelling | doaj-art-90065fc1d1df4e4c9b54e3b019d2bf2d2025-08-20T03:22:54ZengBMCJournal of Translational Medicine1479-58762025-06-0123111810.1186/s12967-025-06228-5Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranosticsFengxian Du0Huiling Wu1Junwei Xue2Shenglan Yao3Ronghui Li4Jinde Zhang5Haitao Wang6Qi Cheng7Fan Zhao8Ying Huang9Zijian Zhou10Feng Liang11Xiufei Gu12Valery V. Tuchin13Qingliang Zhao14The State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityThe Institute of Advanced Science FacilitiesBeiJing HealthOLight Technology Co. LtdBeiJing HealthOLight Technology Co. LtdShengjing Hospital of China Medical UniversityShengjing Hospital of China Medical UniversityThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversitySenior Department of General Surgery, The First Medical Center of Chinese, PLA General HospitalThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityInstitute of Physics and Science Medical Center, Saratov State UniversityThe State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Medical Oncology, Department of ICU, School of Medicine, School of Public Health, Xiang’an Hospital of Xiamen University, Xiamen UniversityAbstract Background Rapid, label-free and depth-resolved imaging of atopic dermatitis (AD) at high resolution has long been a challenge due to current dermoscopes are limited by inadequate resolution, sensitivity and the lack of three-dimensional (3D) imaging capability. Methods Herein, we present promising optical coherence tomography (OCT) and OCT angiography (OCTA) collaborative multi-parameter image processing algorithms (OCT/OCTA) that have been developed for long-term, dynamic longitudinal investigation of subtly changes in tissue structure during the dynamic development of AD, especially in the microvascular network. Results The OCT image demonstrated a ‘roller-coaster’ trend in skin thickness throughout the progression of dermatitis, initially exhibiting an increase and subsequently a decrease. Moreover, the OCTA image enabled the discernment of a displacement of the superficial vascular plexus to deeper layers as the severity of AD increased. Furthermore, the results of the quantitative analysis of vascular multiparametric features at different stages, including vessel diameter, length, and density, also demonstrated a positive correlation with the severity of AD. Conclusion Overall, the full-cycle dynamic changes in skin thickness and depth-resolved vascular alterations during the progression of dermatitis can be effectively predicted using OCT/OCTA, which can inform more targeted AD diagnosis and treatment strategies. Furthermore, this method has the potential to assess therapeutic drug efficacy by capturing microvascular and structural responses across different stages of treatment. The presented methods have the potential to provide new insight into the monitoring of long-term vascular and tissue structure responses before and after therapeutic intervention in a range of AD-related skin diseases.https://doi.org/10.1186/s12967-025-06228-5Optical coherence tomographyOptical Micro-angiographyAtopic dermatitisInflammatoryLong-term observation |
| spellingShingle | Fengxian Du Huiling Wu Junwei Xue Shenglan Yao Ronghui Li Jinde Zhang Haitao Wang Qi Cheng Fan Zhao Ying Huang Zijian Zhou Feng Liang Xiufei Gu Valery V. Tuchin Qingliang Zhao Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics Journal of Translational Medicine Optical coherence tomography Optical Micro-angiography Atopic dermatitis Inflammatory Long-term observation |
| title | Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics |
| title_full | Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics |
| title_fullStr | Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics |
| title_full_unstemmed | Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics |
| title_short | Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics |
| title_sort | long term investigation of 3d tissue detailed structure and multiparametric vascular network properties using oct octa for guiding atopic dermatitis theranostics |
| topic | Optical coherence tomography Optical Micro-angiography Atopic dermatitis Inflammatory Long-term observation |
| url | https://doi.org/10.1186/s12967-025-06228-5 |
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