Targeting PIK3CB/YAP1 improves the sensitivity of paclitaxel by suppressing aging in head and neck squamous tumor cells

Targeting PIK3CB/YAP1 improves the sensitivity of paclitaxel by suppressing aging in head and neck squamous tumor cells

Abstract Background Tumor cell senescence reduces sensitivity to anticancer drugs, making senescent cell elimination an ideal strategy to enhance chemotherapy sensitivity. The interaction between the PI3K/Akt and Hippo/YAP1 pathways is increasingly studied, but the role of PIK3CB, YAP1, and their im...

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Bibliographic Details
Main Authors: Junzhi Liu, Huimin Li, Ruotong Sun, Guoguang Ying, Zheng Liang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Online Access:https://doi.org/10.1186/s12935-025-03818-7
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