Dysbiosis and extraintestinal cancers
Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances in the remarkable correlation between dysbiosis and extraintestinal cancers, the underlying mechanisms are yet to be fully elucidated. Pathogenic m...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-025-03313-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861483319066624 |
|---|---|
| author | Ruishan He Pingqian Qi Linzhen Shu Yidan Ding Peng Zeng Guosheng Wen Ying Xiong Huan Deng |
| author_facet | Ruishan He Pingqian Qi Linzhen Shu Yidan Ding Peng Zeng Guosheng Wen Ying Xiong Huan Deng |
| author_sort | Ruishan He |
| collection | DOAJ |
| description | Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances in the remarkable correlation between dysbiosis and extraintestinal cancers, the underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their metabolites, can undermine the integrity of the gut barrier through inflammatory or metabolic pathways, leading to increased permeability and the translocation of pathogens. The dissemination of pathogens through the circulation may contribute to the establishment of an immune-suppressive environment that promotes carcinogenesis in extraintestinal organs either directly or indirectly. The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. This review aims to comprehensively summarize the existing evidence that points to the potential role of dysbiosis in the malignant transformation of extraintestinal organs such as the liver, breast, lung, and pancreas. Additionally, we delve into the limitations inherent in current methodologies, particularly the challenges associated with differentiating low loads gut-derived microbiome within tumors from potential sample contamination or symbiotic microorganisms. Although still controversial, an understanding of the contribution of translocated intestinal microbiota and their metabolites to the pathological continuum from chronic inflammation to tumors could offer a novel foundation for the development of targeted therapeutics. |
| format | Article |
| id | doaj-art-90017ee830594012bb4b7e408e880a75 |
| institution | Kabale University |
| issn | 1756-9966 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-90017ee830594012bb4b7e408e880a752025-02-09T12:59:55ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662025-02-0144112110.1186/s13046-025-03313-xDysbiosis and extraintestinal cancersRuishan He0Pingqian Qi1Linzhen Shu2Yidan Ding3Peng Zeng4Guosheng Wen5Ying Xiong6Huan Deng7The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang UniversityThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang UniversityThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang UniversityThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Breast Surgery, Jiangxi Armed Police Corps HospitalThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of General Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang UniversityAbstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances in the remarkable correlation between dysbiosis and extraintestinal cancers, the underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their metabolites, can undermine the integrity of the gut barrier through inflammatory or metabolic pathways, leading to increased permeability and the translocation of pathogens. The dissemination of pathogens through the circulation may contribute to the establishment of an immune-suppressive environment that promotes carcinogenesis in extraintestinal organs either directly or indirectly. The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. This review aims to comprehensively summarize the existing evidence that points to the potential role of dysbiosis in the malignant transformation of extraintestinal organs such as the liver, breast, lung, and pancreas. Additionally, we delve into the limitations inherent in current methodologies, particularly the challenges associated with differentiating low loads gut-derived microbiome within tumors from potential sample contamination or symbiotic microorganisms. Although still controversial, an understanding of the contribution of translocated intestinal microbiota and their metabolites to the pathological continuum from chronic inflammation to tumors could offer a novel foundation for the development of targeted therapeutics.https://doi.org/10.1186/s13046-025-03313-xMicrobiotaDysbiosisExtraintestinal cancersCarcinogenesisInflammation |
| spellingShingle | Ruishan He Pingqian Qi Linzhen Shu Yidan Ding Peng Zeng Guosheng Wen Ying Xiong Huan Deng Dysbiosis and extraintestinal cancers Journal of Experimental & Clinical Cancer Research Microbiota Dysbiosis Extraintestinal cancers Carcinogenesis Inflammation |
| title | Dysbiosis and extraintestinal cancers |
| title_full | Dysbiosis and extraintestinal cancers |
| title_fullStr | Dysbiosis and extraintestinal cancers |
| title_full_unstemmed | Dysbiosis and extraintestinal cancers |
| title_short | Dysbiosis and extraintestinal cancers |
| title_sort | dysbiosis and extraintestinal cancers |
| topic | Microbiota Dysbiosis Extraintestinal cancers Carcinogenesis Inflammation |
| url | https://doi.org/10.1186/s13046-025-03313-x |
| work_keys_str_mv | AT ruishanhe dysbiosisandextraintestinalcancers AT pingqianqi dysbiosisandextraintestinalcancers AT linzhenshu dysbiosisandextraintestinalcancers AT yidanding dysbiosisandextraintestinalcancers AT pengzeng dysbiosisandextraintestinalcancers AT guoshengwen dysbiosisandextraintestinalcancers AT yingxiong dysbiosisandextraintestinalcancers AT huandeng dysbiosisandextraintestinalcancers |