A fresh look at angiogenesis in juvenile idiopathic arthritis
Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2018-10-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/A-fresh-look-at-angiogenesis-in-juvenile-idiopathic-arthritis,10,34294,1,1.html |
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| author | Joanna Świdrowska-Jaros Elżbieta Smolewska |
| author_facet | Joanna Świdrowska-Jaros Elżbieta Smolewska |
| author_sort | Joanna Świdrowska-Jaros |
| collection | DOAJ |
| description | Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a key regulator. The role of proangiogenic factors in the pathogenesis of chronic arthritis is currently a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, to a limited extent, in children with juvenile idiopathic arthritis (JIA). Recent studies has shown a significant correlation between proangiogenic marker concentrations and the severity of inflammation in either RA or JIA patients. The serum neovascularization markers correlate with the power Doppler ultrasound image of the inflamed joint and hypertrophic synovium, which may be connected with the disease activity.
The aim of this paper is to describe the state of the art on the important role of angiogenesis in adult and childhood rheumatoid arthritis. |
| format | Article |
| id | doaj-art-8ffe569b0fee4933a5377a4e1cccfa90 |
| institution | OA Journals |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-8ffe569b0fee4933a5377a4e1cccfa902025-08-20T02:09:25ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242018-10-0143332533010.5114/ceji.2018.8005234294A fresh look at angiogenesis in juvenile idiopathic arthritisJoanna Świdrowska-JarosElżbieta SmolewskaAngiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a key regulator. The role of proangiogenic factors in the pathogenesis of chronic arthritis is currently a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, to a limited extent, in children with juvenile idiopathic arthritis (JIA). Recent studies has shown a significant correlation between proangiogenic marker concentrations and the severity of inflammation in either RA or JIA patients. The serum neovascularization markers correlate with the power Doppler ultrasound image of the inflamed joint and hypertrophic synovium, which may be connected with the disease activity. The aim of this paper is to describe the state of the art on the important role of angiogenesis in adult and childhood rheumatoid arthritis.https://www.termedia.pl/A-fresh-look-at-angiogenesis-in-juvenile-idiopathic-arthritis,10,34294,1,1.htmlangiogenesis juvenile idiopathic arthritis rheumatoid arthritis ultrasound |
| spellingShingle | Joanna Świdrowska-Jaros Elżbieta Smolewska A fresh look at angiogenesis in juvenile idiopathic arthritis Central European Journal of Immunology angiogenesis juvenile idiopathic arthritis rheumatoid arthritis ultrasound |
| title | A fresh look at angiogenesis in juvenile idiopathic arthritis |
| title_full | A fresh look at angiogenesis in juvenile idiopathic arthritis |
| title_fullStr | A fresh look at angiogenesis in juvenile idiopathic arthritis |
| title_full_unstemmed | A fresh look at angiogenesis in juvenile idiopathic arthritis |
| title_short | A fresh look at angiogenesis in juvenile idiopathic arthritis |
| title_sort | fresh look at angiogenesis in juvenile idiopathic arthritis |
| topic | angiogenesis juvenile idiopathic arthritis rheumatoid arthritis ultrasound |
| url | https://www.termedia.pl/A-fresh-look-at-angiogenesis-in-juvenile-idiopathic-arthritis,10,34294,1,1.html |
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