Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders
Perioperative neurocognitive disorders (PND), including postoperative delirium, preoperatively cognitive impairment, postoperative cognitive dysfunction, and delayed neurocognitive recovery, represent common complications following anesthesia and surgery, especially in the elderly. As the global pop...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1582909/full |
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| author | Qun Zhou Tuo Chen Tuo Chen Xiaoying Wang Zhongnan Xu Yue Song Shan Liu Yali Ge Ju Gao |
| author_facet | Qun Zhou Tuo Chen Tuo Chen Xiaoying Wang Zhongnan Xu Yue Song Shan Liu Yali Ge Ju Gao |
| author_sort | Qun Zhou |
| collection | DOAJ |
| description | Perioperative neurocognitive disorders (PND), including postoperative delirium, preoperatively cognitive impairment, postoperative cognitive dysfunction, and delayed neurocognitive recovery, represent common complications following anesthesia and surgery, especially in the elderly. As the global population ages, PND is receiving increasing attention due to its prolonged the hospitalization, reduced quality of life and elevated mortality rate. A growing body of evidence has been suggested that the gut-brain axis, a communication system between the gut microbiota and the neuroinflammation, plays a critical role in the development and progression of cognitive impairment. Perioperative interventions, including anesthesia, surgical stress, result in gut microbiota dysbiosis and subsequently trigger neuroinflammation. Therefore, it is necessary to clarify the underlying mechanistic associations between the gut microbiota and the neuroinflammation during PND progression. In this review, we synthesize current knowledge on the mechanistic interplay between gut microbiota dysbiosis and neuroinflammation in PND pathogenesis, which provide reasonable and novel therapeutic approaches targeting the gut-brain axis for PND. |
| format | Article |
| id | doaj-art-8ffa485908024bd0aff0851788689cb7 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-8ffa485908024bd0aff0851788689cb72025-08-20T03:50:12ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-07-011510.3389/fcimb.2025.15829091582909Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disordersQun Zhou0Tuo Chen1Tuo Chen2Xiaoying Wang3Zhongnan Xu4Yue Song5Shan Liu6Yali Ge7Ju Gao8Department of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaPerioperative neurocognitive disorders (PND), including postoperative delirium, preoperatively cognitive impairment, postoperative cognitive dysfunction, and delayed neurocognitive recovery, represent common complications following anesthesia and surgery, especially in the elderly. As the global population ages, PND is receiving increasing attention due to its prolonged the hospitalization, reduced quality of life and elevated mortality rate. A growing body of evidence has been suggested that the gut-brain axis, a communication system between the gut microbiota and the neuroinflammation, plays a critical role in the development and progression of cognitive impairment. Perioperative interventions, including anesthesia, surgical stress, result in gut microbiota dysbiosis and subsequently trigger neuroinflammation. Therefore, it is necessary to clarify the underlying mechanistic associations between the gut microbiota and the neuroinflammation during PND progression. In this review, we synthesize current knowledge on the mechanistic interplay between gut microbiota dysbiosis and neuroinflammation in PND pathogenesis, which provide reasonable and novel therapeutic approaches targeting the gut-brain axis for PND.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1582909/fullperioperative neurocognitive disordersgut microbiotaneuroinflammationeldergut-brain axis |
| spellingShingle | Qun Zhou Tuo Chen Tuo Chen Xiaoying Wang Zhongnan Xu Yue Song Shan Liu Yali Ge Ju Gao Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders Frontiers in Cellular and Infection Microbiology perioperative neurocognitive disorders gut microbiota neuroinflammation elder gut-brain axis |
| title | Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders |
| title_full | Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders |
| title_fullStr | Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders |
| title_full_unstemmed | Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders |
| title_short | Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders |
| title_sort | role of gut microbiota in neuroinflammation a focus on perioperative neurocognitive disorders |
| topic | perioperative neurocognitive disorders gut microbiota neuroinflammation elder gut-brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1582909/full |
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