Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers
Introduction. Silicosis is a disease that most often occurred as a result of silica dust exposure. Silica dust particles will stimulate alveolar macrophages to secrete proinflammatory mediators for fibroblast proliferation and collagen deposition. TGF-ß1 is one of the most extensively involved media...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2019-06-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/311/190 |
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| author | I Putu Eka Krisnha Wijaya Ida Bagus Ngurah Rai I Putu Andrika |
| author_facet | I Putu Eka Krisnha Wijaya Ida Bagus Ngurah Rai I Putu Andrika |
| author_sort | I Putu Eka Krisnha Wijaya |
| collection | DOAJ |
| description | Introduction. Silicosis is a disease that most often occurred as a result of silica dust exposure. Silica dust particles will stimulate alveolar macrophages to secrete proinflammatory mediators for fibroblast proliferation and collagen deposition. TGF-ß1 is one of the most extensively involved mediators in the development of fibrosis. To date, several studies have not shown consistent results regarding the association between silica dust exposure and TGF-β1. This study examined silica dust exposure and serum TGF-β1, which aims to determine the risk of silicosis in stone quarry workers.
Methods. An analytic cross-sectional study was conducted at Company X, Karangasem in March 2016. The studied variables were silica dust exposure using nephelometer dust monitoring, serum TGF-β1 using ELISA method, nutritional status from weight scales, with age, smoking, and use of personal protective equipment (PPE) from an interview. Spearman correlation test is used to determine the correlation between silica dust exposure with serum TGF-β1. Multivariate linear regression analysis was used to asses the effect of silica dust exposure, age, nutritional status, cigarette smoking, and use of PPE with TGF-β1 serum.
Results. There were 55 samples of stone quarry workers in this study. From the Spearman correlation test, there was a significant correlation between silica dust exposure with serum TGF-β1¬, (r) = 0.319, p = 0.018. In multivariate regression analyzes test, there were significant associations between silica dust exposure and nutritional status with serum TGF-β1, p = 0.042 and p = 0.012.
Conclusions. There was an association between silica dust exposure and increasing serum TGF-β1 of stone quarry workers. |
| format | Article |
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| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2019-06-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-8ffa45f5917345cc97bfd9cedfa1722c2025-08-20T02:23:01ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212019-06-01626470http://dx.doi.org/10.7454/jpdi.v6i2.311Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry WorkersI Putu Eka Krisnha Wijaya0Ida Bagus Ngurah Rai1I Putu Andrika2Program Studi Spesialis Ilmu Penyakit Paru, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar Indonesia Program Studi Spesialis Ilmu Penyakit Paru, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar Indonesia Divisi Respirologi dan Penyakit Kritis, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar Indonesia Introduction. Silicosis is a disease that most often occurred as a result of silica dust exposure. Silica dust particles will stimulate alveolar macrophages to secrete proinflammatory mediators for fibroblast proliferation and collagen deposition. TGF-ß1 is one of the most extensively involved mediators in the development of fibrosis. To date, several studies have not shown consistent results regarding the association between silica dust exposure and TGF-β1. This study examined silica dust exposure and serum TGF-β1, which aims to determine the risk of silicosis in stone quarry workers. Methods. An analytic cross-sectional study was conducted at Company X, Karangasem in March 2016. The studied variables were silica dust exposure using nephelometer dust monitoring, serum TGF-β1 using ELISA method, nutritional status from weight scales, with age, smoking, and use of personal protective equipment (PPE) from an interview. Spearman correlation test is used to determine the correlation between silica dust exposure with serum TGF-β1. Multivariate linear regression analysis was used to asses the effect of silica dust exposure, age, nutritional status, cigarette smoking, and use of PPE with TGF-β1 serum. Results. There were 55 samples of stone quarry workers in this study. From the Spearman correlation test, there was a significant correlation between silica dust exposure with serum TGF-β1¬, (r) = 0.319, p = 0.018. In multivariate regression analyzes test, there were significant associations between silica dust exposure and nutritional status with serum TGF-β1, p = 0.042 and p = 0.012. Conclusions. There was an association between silica dust exposure and increasing serum TGF-β1 of stone quarry workers.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/311/190Serum TGF-β1Silica dust exposureStone quarry workers |
| spellingShingle | I Putu Eka Krisnha Wijaya Ida Bagus Ngurah Rai I Putu Andrika Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers Jurnal Penyakit Dalam Indonesia Serum TGF-β1 Silica dust exposure Stone quarry workers |
| title | Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers |
| title_full | Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers |
| title_fullStr | Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers |
| title_full_unstemmed | Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers |
| title_short | Association between Silica Dust Exposure and Serum Transforming Growth Factor-β1 in Stone Quarry Workers |
| title_sort | association between silica dust exposure and serum transforming growth factor β1 in stone quarry workers |
| topic | Serum TGF-β1 Silica dust exposure Stone quarry workers |
| url | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/311/190 |
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