Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people
Postoperative cognitive dysfunction (POCD) is a common complication among elderly patients following surgical procedures, significantly impairing postoperative recovery and quality of life. The selection and dosage of intraoperative anaesthetic drugs are frequently implicated as contributing factors...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1508661/full |
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| author | Yuanbin Cai Fan Yu Wei Wu Wurong Chen |
| author_facet | Yuanbin Cai Fan Yu Wei Wu Wurong Chen |
| author_sort | Yuanbin Cai |
| collection | DOAJ |
| description | Postoperative cognitive dysfunction (POCD) is a common complication among elderly patients following surgical procedures, significantly impairing postoperative recovery and quality of life. The selection and dosage of intraoperative anaesthetic drugs are frequently implicated as contributing factors in the development of POCD. In recent years, dexmedetomidine (DEX), a novel α2-adrenoceptor agonist, has been increasingly utilized in surgical anaesthesia for elderly patients, showing potential as both a preventive and therapeutic agent for POCD. This paper provides a comprehensive review of current research on the mechanisms by which DEX affects POCD in the elderly. Additionally, it explores DEX’s mechanisms of action in the context of neuroprotection, anti-inflammation, antioxidative stress, and the regulation of apoptosis, autophagy, and analgesia. The objective is to provide reliable theoretical support and a reference point for the clinical application of DEX in POCD among the elderly, thereby promoting its broader use in clinical practice to improve outcomes and enhance quality of life. |
| format | Article |
| id | doaj-art-8ff67f26c9bd420db5cbecc3227410b4 |
| institution | OA Journals |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-8ff67f26c9bd420db5cbecc3227410b42025-08-20T02:04:37ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-03-011610.3389/fphys.2025.15086611508661Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly peopleYuanbin Cai0Fan Yu1Wei Wu2Wurong Chen3Department of Anesthesiology, Putuo District Central Hospital, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Anesthesiology, Putuo District Central Hospital, Shanghai, ChinaPostoperative cognitive dysfunction (POCD) is a common complication among elderly patients following surgical procedures, significantly impairing postoperative recovery and quality of life. The selection and dosage of intraoperative anaesthetic drugs are frequently implicated as contributing factors in the development of POCD. In recent years, dexmedetomidine (DEX), a novel α2-adrenoceptor agonist, has been increasingly utilized in surgical anaesthesia for elderly patients, showing potential as both a preventive and therapeutic agent for POCD. This paper provides a comprehensive review of current research on the mechanisms by which DEX affects POCD in the elderly. Additionally, it explores DEX’s mechanisms of action in the context of neuroprotection, anti-inflammation, antioxidative stress, and the regulation of apoptosis, autophagy, and analgesia. The objective is to provide reliable theoretical support and a reference point for the clinical application of DEX in POCD among the elderly, thereby promoting its broader use in clinical practice to improve outcomes and enhance quality of life.https://www.frontiersin.org/articles/10.3389/fphys.2025.1508661/fullpostoperative cognitive dysfunctiondexmedetomidineelderlymechanismseffect |
| spellingShingle | Yuanbin Cai Fan Yu Wei Wu Wurong Chen Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people Frontiers in Physiology postoperative cognitive dysfunction dexmedetomidine elderly mechanisms effect |
| title | Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people |
| title_full | Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people |
| title_fullStr | Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people |
| title_full_unstemmed | Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people |
| title_short | Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people |
| title_sort | study on the mechanism of dexmedetomidine s effect on postoperative cognitive dysfunction in elderly people |
| topic | postoperative cognitive dysfunction dexmedetomidine elderly mechanisms effect |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1508661/full |
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