Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping
Introduction Rectal cancer is one of the top 10 cancers worldwide. Up to 80% of patients with rectal tumours have had sphincter-saving surgery, mainly due to the large expectation of anal preservation. However, patients tend to experience low anterior resection syndrome (LARS) after rectal resection...
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BMJ Publishing Group
2023-12-01
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| Series: | BMJ Open |
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| author | Yang Li Quan Wang Xin-Yu Zhang Ke-Lu Yang Xiao-Nan Liu Rui-Shu Li Shi-Qi Wang |
| author_facet | Yang Li Quan Wang Xin-Yu Zhang Ke-Lu Yang Xiao-Nan Liu Rui-Shu Li Shi-Qi Wang |
| author_sort | Yang Li |
| collection | DOAJ |
| description | Introduction Rectal cancer is one of the top 10 cancers worldwide. Up to 80% of patients with rectal tumours have had sphincter-saving surgery, mainly due to the large expectation of anal preservation. However, patients tend to experience low anterior resection syndrome (LARS) after rectal resection, which is disordered bowel function that includes faecal incontinence, urgency, frequent defecation, constipation and evacuation difficulties. LARS, with an estimated prevalence of 41%, has been reported to substantially decrease the quality of life of patients. However, no comprehensive preventive strategies are currently available for LARS. This systematic review aims to synthesise evidence on the current LARS preventive strategies.Methods and analysis This protocol is reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist. Literature in PubMed (via Medline), Embase and the Cochrane Library from inception to July 2023 will be searched to identify articles relevant to preventive effectiveness against LARS. The Cochrane Collaboration’s risk of bias tool for randomised controlled trials and the Newcastle-Ottawa Scale for clinical controlled trials, cohort studies and case–control studies will be used to assess the risk of bias. We will group the included studies by the type of LARS prevention strategy and present an overview of the main findings in the form of evidence mapping. A meta-analysis is planned if there is no substantial clinical heterogeneity between the included studies. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) will be used to evaluate the quality of the evidence.Ethics and dissemination Ethical approval is not needed for systematic review of published data. The findings will be published in a peer-reviewed journal and disseminated at scientific conferences.PROSPERO registration number CRD42023402886. |
| format | Article |
| id | doaj-art-8ff44d10d0cc42c7bcee0667fdcadbc6 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8ff44d10d0cc42c7bcee0667fdcadbc62025-08-20T02:11:12ZengBMJ Publishing GroupBMJ Open2044-60552023-12-01131210.1136/bmjopen-2023-077279Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mappingYang Li0Quan Wang1Xin-Yu Zhang2Ke-Lu Yang3Xiao-Nan Liu4Rui-Shu Li5Shi-Qi Wang6Department of Rheumatology and Immunology, Guangdong People`s Hospital, Guangzhou, Guangdong, ChinaAmbulatory Surgery Center, Xijing Hospital, Air Force Military Medical University, Xi`an, ChinaAmbulatory Surgery Center, Xijing Hospital, Air Force Military Medical University, Xi`an, ChinaAcademic Center for Nursing and Midwifery, Department of Public Health and Primary Care, University of Leuven (KU Leuven), Leuven, BelgiumAmbulatory Surgery Center, Xijing Hospital, Air Force Military Medical University, Xi`an, ChinaAmbulatory Surgery Center, Xijing Hospital, Air Force Military Medical University, Xi`an, ChinaDepartment of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, Xijing Hospital, Air Force Military Medical University, Xi`an, ChinaIntroduction Rectal cancer is one of the top 10 cancers worldwide. Up to 80% of patients with rectal tumours have had sphincter-saving surgery, mainly due to the large expectation of anal preservation. However, patients tend to experience low anterior resection syndrome (LARS) after rectal resection, which is disordered bowel function that includes faecal incontinence, urgency, frequent defecation, constipation and evacuation difficulties. LARS, with an estimated prevalence of 41%, has been reported to substantially decrease the quality of life of patients. However, no comprehensive preventive strategies are currently available for LARS. This systematic review aims to synthesise evidence on the current LARS preventive strategies.Methods and analysis This protocol is reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist. Literature in PubMed (via Medline), Embase and the Cochrane Library from inception to July 2023 will be searched to identify articles relevant to preventive effectiveness against LARS. The Cochrane Collaboration’s risk of bias tool for randomised controlled trials and the Newcastle-Ottawa Scale for clinical controlled trials, cohort studies and case–control studies will be used to assess the risk of bias. We will group the included studies by the type of LARS prevention strategy and present an overview of the main findings in the form of evidence mapping. A meta-analysis is planned if there is no substantial clinical heterogeneity between the included studies. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) will be used to evaluate the quality of the evidence.Ethics and dissemination Ethical approval is not needed for systematic review of published data. The findings will be published in a peer-reviewed journal and disseminated at scientific conferences.PROSPERO registration number CRD42023402886.https://bmjopen.bmj.com/content/13/12/e077279.full |
| spellingShingle | Yang Li Quan Wang Xin-Yu Zhang Ke-Lu Yang Xiao-Nan Liu Rui-Shu Li Shi-Qi Wang Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping BMJ Open |
| title | Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping |
| title_full | Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping |
| title_fullStr | Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping |
| title_full_unstemmed | Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping |
| title_short | Preventive strategies for low anterior resection syndrome: a protocol for systematic review and evidence mapping |
| title_sort | preventive strategies for low anterior resection syndrome a protocol for systematic review and evidence mapping |
| url | https://bmjopen.bmj.com/content/13/12/e077279.full |
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