SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE
Socioeconomic status (SES) is reflecting differences in sociodemographic factors affecting cancer survivorship. Deprived, low SES populations has a higher prevalence of multiple myeloma and worst survival, a gap that widens over time. Methods: We performed a meta-analysis of 16 studies (registries...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/4369 |
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| author | Stergios Intzes Marianthi Symeonidou Konstantinos Zagoridis Aikaterini Pentidou Spanoudakis Emmanouil |
| author_facet | Stergios Intzes Marianthi Symeonidou Konstantinos Zagoridis Aikaterini Pentidou Spanoudakis Emmanouil |
| author_sort | Stergios Intzes |
| collection | DOAJ |
| description | Socioeconomic status (SES) is reflecting differences in sociodemographic factors affecting cancer survivorship. Deprived, low SES populations has a higher prevalence of multiple myeloma and worst survival, a gap that widens over time.
Methods: We performed a meta-analysis of 16 studies (registries and cohorts) reporting survival data of myeloma patients according to SES. Ten studies reported Hazzard Ratio (HR) (95 % CI) and 16 studies reported p values. We combined the HR from 10 studies and by using the Mosteller-Bush formula we performed the synthesis of p values according to the area of the globe.
Results: A combination of HR from 10 studies including 85198 myeloma patients weighted to sample size of each study and adopting the hypothesis of random effect returned a combined HR: 1,26 (1,13-1,31) in favor of high SES patients.
USA: Synthesis of p values coming from 6 studies (n=89807 pts) by using the Mosteller and Bush formula extracted a p-value of <0.0001 favoring high SES patients
Oceania: Synthesis of p values in two cohorts from Australia and New Zealand (n= 10196 pts) returned a p-value of 0,022 favoring high SES patients
Europe: The synthesis of p values from UK and Greece studies (n=18533 pts) returned a p-value of <0,0001 favoring high SES patients
Asia: Synthesis of 2 studies from Asia (n=915 pts) returned a p-value of <0,0001 favoring high SES patients
Conclusions: Across the globe and widening over decades socioeconomic status remains a gap for equality in myeloma care |
| format | Article |
| id | doaj-art-8fedb44db9ca4e1fbf7a6061c8f12969 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-8fedb44db9ca4e1fbf7a6061c8f129692025-08-20T01:47:40ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062021-01-0113110.4084/mjhid.2021.006SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATUREStergios Intzes0Marianthi Symeonidou1Konstantinos Zagoridis2Aikaterini Pentidou3Spanoudakis Emmanouil4Democritus University of ThraceDemocritus University of ThraceDemocritus University of ThraceDemocritus University of ThraceDemocritus University of ThraceSocioeconomic status (SES) is reflecting differences in sociodemographic factors affecting cancer survivorship. Deprived, low SES populations has a higher prevalence of multiple myeloma and worst survival, a gap that widens over time. Methods: We performed a meta-analysis of 16 studies (registries and cohorts) reporting survival data of myeloma patients according to SES. Ten studies reported Hazzard Ratio (HR) (95 % CI) and 16 studies reported p values. We combined the HR from 10 studies and by using the Mosteller-Bush formula we performed the synthesis of p values according to the area of the globe. Results: A combination of HR from 10 studies including 85198 myeloma patients weighted to sample size of each study and adopting the hypothesis of random effect returned a combined HR: 1,26 (1,13-1,31) in favor of high SES patients. USA: Synthesis of p values coming from 6 studies (n=89807 pts) by using the Mosteller and Bush formula extracted a p-value of <0.0001 favoring high SES patients Oceania: Synthesis of p values in two cohorts from Australia and New Zealand (n= 10196 pts) returned a p-value of 0,022 favoring high SES patients Europe: The synthesis of p values from UK and Greece studies (n=18533 pts) returned a p-value of <0,0001 favoring high SES patients Asia: Synthesis of 2 studies from Asia (n=915 pts) returned a p-value of <0,0001 favoring high SES patients Conclusions: Across the globe and widening over decades socioeconomic status remains a gap for equality in myeloma carehttp://www.mjhid.org/index.php/mjhid/article/view/4369myelomasocioeconomic status |
| spellingShingle | Stergios Intzes Marianthi Symeonidou Konstantinos Zagoridis Aikaterini Pentidou Spanoudakis Emmanouil SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE Mediterranean Journal of Hematology and Infectious Diseases myeloma socioeconomic status |
| title | SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE |
| title_full | SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE |
| title_fullStr | SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE |
| title_full_unstemmed | SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE |
| title_short | SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE |
| title_sort | socioeconomic status is globally a prognostic factor for overall survival of multiple myeloma patients synthesis of studies and review of the literature |
| topic | myeloma socioeconomic status |
| url | http://www.mjhid.org/index.php/mjhid/article/view/4369 |
| work_keys_str_mv | AT stergiosintzes socioeconomicstatusisgloballyaprognosticfactorforoverallsurvivalofmultiplemyelomapatientssynthesisofstudiesandreviewoftheliterature AT marianthisymeonidou socioeconomicstatusisgloballyaprognosticfactorforoverallsurvivalofmultiplemyelomapatientssynthesisofstudiesandreviewoftheliterature AT konstantinoszagoridis socioeconomicstatusisgloballyaprognosticfactorforoverallsurvivalofmultiplemyelomapatientssynthesisofstudiesandreviewoftheliterature AT aikaterinipentidou socioeconomicstatusisgloballyaprognosticfactorforoverallsurvivalofmultiplemyelomapatientssynthesisofstudiesandreviewoftheliterature AT spanoudakisemmanouil socioeconomicstatusisgloballyaprognosticfactorforoverallsurvivalofmultiplemyelomapatientssynthesisofstudiesandreviewoftheliterature |