Peroxisome Proliferator-Activated Receptors and Shock State
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors. Three isotypes of PPARs have been identified: alpha, beta/delta, and gamma, enco...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.298 |
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| author | Emanuela Esposito Salvatore Cuzzocrea Rosaria Meli |
| author_facet | Emanuela Esposito Salvatore Cuzzocrea Rosaria Meli |
| author_sort | Emanuela Esposito |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors. Three isotypes of PPARs have been identified: alpha, beta/delta, and gamma, encoded by different genes and distributed in various tissues. PPARs are implicated in the control of inflammatory responses and in energy homeostasis and, thus, can be defined as metabolic and anti-inflammatory transcription factors. They exert anti-inflammatory effects by inhibiting the induction of proinflammatory cytokines, adhesion molecules, and extracellular matrix proteins, or by stimulating the production of anti-inflammatory molecules. Moreover, PPARs modulate the proliferation, differentiation, and survival of immune cells. This review presents the current state of knowledge regarding the involvement of PPARs in the control of inflammatory response, and their potential therapeutic applications in several types of shock, as well as hemorrhagic, septic, and nonseptic shock. |
| format | Article |
| id | doaj-art-8fe98285c168466cb8db25d3e703df43 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8fe98285c168466cb8db25d3e703df432025-08-20T03:37:05ZengWileyThe Scientific World Journal1537-744X2006-01-0161770178210.1100/tsw.2006.298Peroxisome Proliferator-Activated Receptors and Shock StateEmanuela Esposito0Salvatore Cuzzocrea1Rosaria Meli2Department of Experimental Pharmacology, University of Naples “Federico II”, Naples, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, ItalyDepartment of Experimental Pharmacology, University of Naples “Federico II”, Naples, ItalyPeroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors. Three isotypes of PPARs have been identified: alpha, beta/delta, and gamma, encoded by different genes and distributed in various tissues. PPARs are implicated in the control of inflammatory responses and in energy homeostasis and, thus, can be defined as metabolic and anti-inflammatory transcription factors. They exert anti-inflammatory effects by inhibiting the induction of proinflammatory cytokines, adhesion molecules, and extracellular matrix proteins, or by stimulating the production of anti-inflammatory molecules. Moreover, PPARs modulate the proliferation, differentiation, and survival of immune cells. This review presents the current state of knowledge regarding the involvement of PPARs in the control of inflammatory response, and their potential therapeutic applications in several types of shock, as well as hemorrhagic, septic, and nonseptic shock.http://dx.doi.org/10.1100/tsw.2006.298 |
| spellingShingle | Emanuela Esposito Salvatore Cuzzocrea Rosaria Meli Peroxisome Proliferator-Activated Receptors and Shock State The Scientific World Journal |
| title | Peroxisome Proliferator-Activated Receptors and Shock State |
| title_full | Peroxisome Proliferator-Activated Receptors and Shock State |
| title_fullStr | Peroxisome Proliferator-Activated Receptors and Shock State |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors and Shock State |
| title_short | Peroxisome Proliferator-Activated Receptors and Shock State |
| title_sort | peroxisome proliferator activated receptors and shock state |
| url | http://dx.doi.org/10.1100/tsw.2006.298 |
| work_keys_str_mv | AT emanuelaesposito peroxisomeproliferatoractivatedreceptorsandshockstate AT salvatorecuzzocrea peroxisomeproliferatoractivatedreceptorsandshockstate AT rosariameli peroxisomeproliferatoractivatedreceptorsandshockstate |