Combination antibacterial effect of compound amoxicillin and levofloxacin hydrochloride nanoemulsion against three main pathogenic bacteria of cow mastitis in vitro
Combination antibacterial effect of compound amoxicillin and levofloxacin hydrochloride nanoemulsion (AMX-LH-NE) against three main pathogenic bacteria of cow mastitis in vitro was investigated by single drug bridging test, compound drug susceptibility test, single drug minimum inhibitory concentrat...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2009-09-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.05.017 |
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| Summary: | Combination antibacterial effect of compound amoxicillin and levofloxacin hydrochloride nanoemulsion (AMX-LH-NE) against three main pathogenic bacteria of cow mastitis in vitro was investigated by single drug bridging test, compound drug susceptibility test, single drug minimum inhibitory concentration (MIC) determination, combination susceptibility test and Kirby-Baueer disc diffusion test. The results show that synergistic effect was generated when amoxicillin (AMX) and levofloxacin hydrochloride (LH) were combined. MIC of the mixed AMX and LH against Staphylococcus aureus was 1/4 and 1/8 times compared with single drug, respectively, and MIC against Streptococcus agalactiae was both 1/4 times, and MIC against Escherichia coli was both 1/8 times. Each of fractional inhibitory concentration (FIC) index was not more than 0.5. The disc diffusion zone diameters of AMX-LH-NE against bacteria were all highly significant difference (P<0.01) compared with other each group. The results above suggested that combination antibacterial activity of AMX-LH-NE against three pathogenic bacteria was strong. |
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| ISSN: | 1008-9209 2097-5155 |