Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility
Compared with the conventional laser cutting and braided method, this research aimed to produce unibody NiTi vascular stents by metal injection molding (MIM), simplifying the manufacturing process. MIM NiTi alloys and stents with a low oxygen content of 0.17 % were obtained via strict oxygen control...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525000449 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595410052448256 |
|---|---|
| author | Dongyang Li Junwei Wang Changhai Du Hao He Zheyu He Tun Wang Chang Shu Yimin Li Jing Pan |
| author_facet | Dongyang Li Junwei Wang Changhai Du Hao He Zheyu He Tun Wang Chang Shu Yimin Li Jing Pan |
| author_sort | Dongyang Li |
| collection | DOAJ |
| description | Compared with the conventional laser cutting and braided method, this research aimed to produce unibody NiTi vascular stents by metal injection molding (MIM), simplifying the manufacturing process. MIM NiTi alloys and stents with a low oxygen content of 0.17 % were obtained via strict oxygen control. Sintered Ni4Ti3 precipitates can be observed in both micron and nanometer scales. The MIM NiTi alloy has a tensile strength of 812 MPa, an elongation of 5.7 %, and full recovery at 5 % pre-strain. During 3.96 × 108 cycle-simulated in vitro fatigue tests, the MIM NiTi stents essentially maintained a constant diameter without any marked damage, although local pitting was observed. The biocompatibility of MIM NiTi was evaluated based on toxicity, migration, and adhesion of the human umbilical vein endothelial cells. The hemolysis rate was as low as 0.4 %. This study provides a new manufacturing strategy for NiTi self-expanding vascular stents. Additionally, it aimed to develop porous and gradient porous NiTi vascular stents using the characteristics of MIM process. |
| format | Article |
| id | doaj-art-8fdbe7968c014d73b3e6d44e2f04448e |
| institution | Kabale University |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-8fdbe7968c014d73b3e6d44e2f04448e2025-01-19T06:24:08ZengElsevierMaterials & Design0264-12752025-02-01250113624Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibilityDongyang Li0Junwei Wang1Changhai Du2Hao He3Zheyu He4Tun Wang5Chang Shu6Yimin Li7Jing Pan8The Second Xiang Ya Hospital, Central South University, Changsha 410083, ChinaThe Second Xiang Ya Hospital, Central South University, Changsha 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, ChinaThe Second Xiang Ya Hospital, Central South University, Changsha 410083, ChinaSchool of Microelectronics and Materials Engineering, Guangxi University of Science and Technology, Liuzhou 545006, ChinaThe Second Xiang Ya Hospital, Central South University, Changsha 410083, ChinaThe Second Xiang Ya Hospital, Central South University, Changsha 410083, China; Corresponding authors.State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China; Corresponding authors.Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410013, ChinaCompared with the conventional laser cutting and braided method, this research aimed to produce unibody NiTi vascular stents by metal injection molding (MIM), simplifying the manufacturing process. MIM NiTi alloys and stents with a low oxygen content of 0.17 % were obtained via strict oxygen control. Sintered Ni4Ti3 precipitates can be observed in both micron and nanometer scales. The MIM NiTi alloy has a tensile strength of 812 MPa, an elongation of 5.7 %, and full recovery at 5 % pre-strain. During 3.96 × 108 cycle-simulated in vitro fatigue tests, the MIM NiTi stents essentially maintained a constant diameter without any marked damage, although local pitting was observed. The biocompatibility of MIM NiTi was evaluated based on toxicity, migration, and adhesion of the human umbilical vein endothelial cells. The hemolysis rate was as low as 0.4 %. This study provides a new manufacturing strategy for NiTi self-expanding vascular stents. Additionally, it aimed to develop porous and gradient porous NiTi vascular stents using the characteristics of MIM process.http://www.sciencedirect.com/science/article/pii/S0264127525000449StentsNiTiMetal injection moldingFatigue propertiesIn vitro tests |
| spellingShingle | Dongyang Li Junwei Wang Changhai Du Hao He Zheyu He Tun Wang Chang Shu Yimin Li Jing Pan Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility Materials & Design Stents NiTi Metal injection molding Fatigue properties In vitro tests |
| title | Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility |
| title_full | Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility |
| title_fullStr | Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility |
| title_full_unstemmed | Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility |
| title_short | Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility |
| title_sort | technical explorations for manufacturing of niti unibody vascular stents through metal injection molding materials performance fatigue properties and biocompatibility |
| topic | Stents NiTi Metal injection molding Fatigue properties In vitro tests |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525000449 |
| work_keys_str_mv | AT dongyangli technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT junweiwang technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT changhaidu technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT haohe technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT zheyuhe technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT tunwang technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT changshu technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT yiminli technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility AT jingpan technicalexplorationsformanufacturingofnitiunibodyvascularstentsthroughmetalinjectionmoldingmaterialsperformancefatiguepropertiesandbiocompatibility |