Primordial Germ Cells: Current Knowledge and Perspectives
Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the p...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1741072 |
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| author | Aleksandar Nikolic Vladislav Volarevic Lyle Armstrong Majlinda Lako Miodrag Stojkovic |
| author_facet | Aleksandar Nikolic Vladislav Volarevic Lyle Armstrong Majlinda Lako Miodrag Stojkovic |
| author_sort | Aleksandar Nikolic |
| collection | DOAJ |
| description | Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell (PGC) is the primary undifferentiated stem cell type that will differentiate towards gametes: spermatozoa or oocytes. With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples. Recent studies demonstrated that viable mouse pups could be obtained from in vitro differentiated stem cells suggesting that translation of these results to human is closer. Therefore, the aim of this review is to summarize current knowledge about PGC indicating the perspective of their use in both research and medical application for the treatment of infertility. |
| format | Article |
| id | doaj-art-8fdaa029292545448af2af4dbf4b3e16 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8fdaa029292545448af2af4dbf4b3e162025-02-03T01:30:35ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/17410721741072Primordial Germ Cells: Current Knowledge and PerspectivesAleksandar Nikolic0Vladislav Volarevic1Lyle Armstrong2Majlinda Lako3Miodrag Stojkovic4Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, SerbiaCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, SerbiaInstitute of Genetic Medicine, Newcastle University, The International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UKInstitute of Genetic Medicine, Newcastle University, The International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UKCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, SerbiaInfertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell (PGC) is the primary undifferentiated stem cell type that will differentiate towards gametes: spermatozoa or oocytes. With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples. Recent studies demonstrated that viable mouse pups could be obtained from in vitro differentiated stem cells suggesting that translation of these results to human is closer. Therefore, the aim of this review is to summarize current knowledge about PGC indicating the perspective of their use in both research and medical application for the treatment of infertility.http://dx.doi.org/10.1155/2016/1741072 |
| spellingShingle | Aleksandar Nikolic Vladislav Volarevic Lyle Armstrong Majlinda Lako Miodrag Stojkovic Primordial Germ Cells: Current Knowledge and Perspectives Stem Cells International |
| title | Primordial Germ Cells: Current Knowledge and Perspectives |
| title_full | Primordial Germ Cells: Current Knowledge and Perspectives |
| title_fullStr | Primordial Germ Cells: Current Knowledge and Perspectives |
| title_full_unstemmed | Primordial Germ Cells: Current Knowledge and Perspectives |
| title_short | Primordial Germ Cells: Current Knowledge and Perspectives |
| title_sort | primordial germ cells current knowledge and perspectives |
| url | http://dx.doi.org/10.1155/2016/1741072 |
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