Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery

Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery

Abstract The geroprotective effects of rapamycin in mitigating frailty and cognitive complications in the perioperative period remains unknown. Of 39 C57BL/6 mice tested, 19 were young (16 weeks), and 20 were old (80 weeks). The interventional group (10 old, 10 young) received daily oral rapamycin f...

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Main Authors: Ming Ann Sim, Jorming Goh, Jasinda Lee, Jian Hua Tay, Francis Chee Kuan Tan, Chunmei Li, Esther S. P. Wong, Will N. H. Loh, Sophia T. H. Chew, Andrea B. Maier, Brian K. Kennedy, Lian Kah Ti
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Aging
Rapamycin
Perioperative
Cognition
Frailty
Anesthesia
Online Access:https://doi.org/10.1038/s41598-025-02707-3
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