Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia
Abstract Background Galectin‐9 and myeloid‐derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been fully elucidated. This study aimed to analyze the prognosis values of Galectin‐9 and MDSCs in CLL. Methods The c...
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| Format: | Article |
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Wiley
2023-05-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.853 |
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| author | Xierenguli Alimu Juan Zhang Nannan Pang Rui Zhang Rong Chen Xuejiao Zeng Shabaaiti Tudahong Gang Chen Maliya Muhashi Fang Zhao Jianbing Ding Jianhua Qu |
| author_facet | Xierenguli Alimu Juan Zhang Nannan Pang Rui Zhang Rong Chen Xuejiao Zeng Shabaaiti Tudahong Gang Chen Maliya Muhashi Fang Zhao Jianbing Ding Jianhua Qu |
| author_sort | Xierenguli Alimu |
| collection | DOAJ |
| description | Abstract Background Galectin‐9 and myeloid‐derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been fully elucidated. This study aimed to analyze the prognosis values of Galectin‐9 and MDSCs in CLL. Methods The concentrations of Galectin‐9, argininase‐1, and inducible nitric oxide synthase in serum were detected by enzyme‐linked immune sorbent assay. The expression of Tim‐3 protein in peripheral blood mononuclear cell was detected by Western blot. Flow cytometry was used to analyze the percentages of Tim‐3 on T‐cells (CD3+T, CD4+T, and CD8+T cells) and MDSCs. Results Our results showed that Galectin‐9 and MDSCs significantly increased in CLL patients and were closely related to the disease progression. Patient's receiver operating characteristic, progression‐free survival, and Cox regression analysis showed that Galectin9 and MDSCs were poor prognostic factors of CLL. Conclusion Galectin‐9 and MDSCs were associated with clinical progression and could be important prognostic indicators for CLL. |
| format | Article |
| id | doaj-art-8fd7cc26b3f9481790547a3a47e84dde |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-8fd7cc26b3f9481790547a3a47e84dde2025-08-20T02:15:41ZengWileyImmunity, Inflammation and Disease2050-45272023-05-01115n/an/a10.1002/iid3.853Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemiaXierenguli Alimu0Juan Zhang1Nannan Pang2Rui Zhang3Rong Chen4Xuejiao Zeng5Shabaaiti Tudahong6Gang Chen7Maliya Muhashi8Fang Zhao9Jianbing Ding10Jianhua Qu11Center of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaSenior Department of Hematology The Fifth Medical Center of PLA General Hospital Beijing ChinaCAS Key Lab of Bio‐Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaDepartment of Immunology, School of Basic Medical Sciences Xinjiang Medical University Urumqi Xinjiang ChinaCenter of Hematology The First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang ChinaAbstract Background Galectin‐9 and myeloid‐derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been fully elucidated. This study aimed to analyze the prognosis values of Galectin‐9 and MDSCs in CLL. Methods The concentrations of Galectin‐9, argininase‐1, and inducible nitric oxide synthase in serum were detected by enzyme‐linked immune sorbent assay. The expression of Tim‐3 protein in peripheral blood mononuclear cell was detected by Western blot. Flow cytometry was used to analyze the percentages of Tim‐3 on T‐cells (CD3+T, CD4+T, and CD8+T cells) and MDSCs. Results Our results showed that Galectin‐9 and MDSCs significantly increased in CLL patients and were closely related to the disease progression. Patient's receiver operating characteristic, progression‐free survival, and Cox regression analysis showed that Galectin9 and MDSCs were poor prognostic factors of CLL. Conclusion Galectin‐9 and MDSCs were associated with clinical progression and could be important prognostic indicators for CLL.https://doi.org/10.1002/iid3.853chronic lymphocytic leukemiaGalectin‐9MDSCsTim‐3 |
| spellingShingle | Xierenguli Alimu Juan Zhang Nannan Pang Rui Zhang Rong Chen Xuejiao Zeng Shabaaiti Tudahong Gang Chen Maliya Muhashi Fang Zhao Jianbing Ding Jianhua Qu Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia Immunity, Inflammation and Disease chronic lymphocytic leukemia Galectin‐9 MDSCs Tim‐3 |
| title | Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia |
| title_full | Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia |
| title_fullStr | Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia |
| title_full_unstemmed | Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia |
| title_short | Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia |
| title_sort | galectin 9 and myeloid derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia |
| topic | chronic lymphocytic leukemia Galectin‐9 MDSCs Tim‐3 |
| url | https://doi.org/10.1002/iid3.853 |
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