Early menopause and premature ovarian insufficiency: problems and perspectives
In this review we summarize current data on prevalence, etiology and pathogenesis resulting in premature ovarian insufficiency (POI). In particular, genetic, autoimmune, metabolic, iatrogenic disorders as well as unfavorable impact of environmental factors represent key pathogenetic mechanisms under...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2020-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/781 |
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| author | D. V. Blinov P. L. Hasan A. N. Mnatsakanyan D. I. Korabelnikov A. T. Safarov N. V. Pavlova N. S. Zakharova D. A. Ponomarev D. A. Petrenko |
| author_facet | D. V. Blinov P. L. Hasan A. N. Mnatsakanyan D. I. Korabelnikov A. T. Safarov N. V. Pavlova N. S. Zakharova D. A. Ponomarev D. A. Petrenko |
| author_sort | D. V. Blinov |
| collection | DOAJ |
| description | In this review we summarize current data on prevalence, etiology and pathogenesis resulting in premature ovarian insufficiency (POI). In particular, genetic, autoimmune, metabolic, iatrogenic disorders as well as unfavorable impact of environmental factors represent key pathogenetic mechanisms underlying POI development. Clinical picture of this disease is mainly manifested by oligo- and amenorrhea as well as genitourinary menopausal syndrome (GUMS). Special attention is paid to a link between such clinical signs and psychosocial discomfort not being a life-threatening condition but still able to markedly lower quality of woman’s life and considered as a comorbidity with type 2 diabetes mellitus, osteoporosis and cardiovascular diseases. Hormone replacement therapy (HRT) serves as the first-line therapeutic approach for treating POI, which is performed according to the principles similar to those used to perform menopausal hormone therapy (MHT) in case of natural menopause that should be continued until reaching at least the average age for the onset of menopause. Topical estriol therapy eliminates GUMS symptoms, which in turn positively affects sexual function and woman’s psychosocial status and contributes to improved quality of life. The data from recent studies examining topical estriol therapy in POI demonstrated high efficacy and safety. Finally, we also discuss diverse strategies to support reproductive function in women with POI. |
| format | Article |
| id | doaj-art-8fd36ee4fcfb4c7fa5beea2c92dde4be |
| institution | Kabale University |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-8fd36ee4fcfb4c7fa5beea2c92dde4be2025-08-20T03:39:39ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942020-09-0114332834510.17749/2313-7347/ob.gyn.rep.2020.173569Early menopause and premature ovarian insufficiency: problems and perspectivesD. V. Blinov0P. L. Hasan1A. N. Mnatsakanyan2D. I. Korabelnikov3A. T. Safarov4N. V. Pavlova5N. S. Zakharova6D. A. Ponomarev7D. A. Petrenko8Institute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical Group; Moscow Haass Medical - Social InstituteResearch Institute of Urology and Interventional Radiology named after N.А. Lopatkin - branch of National Medical Research Radiological Centre, Health Ministry of Russian FederationNational Research University «Higher School of Economics»Moscow Haass Medical - Social InstituteSamarkand State Medical InstituteMoscow State University of Medicine and Dentistry named after А.I. Evdokimov, Health Ministry of Russian FederationSamarkand State Medical InstituteMaternity Hospital № 4 - Branch of City Clinical Hospital named after V.V. Vinogradov, Moscow Healthcare DepartmentSechenov UniversityIn this review we summarize current data on prevalence, etiology and pathogenesis resulting in premature ovarian insufficiency (POI). In particular, genetic, autoimmune, metabolic, iatrogenic disorders as well as unfavorable impact of environmental factors represent key pathogenetic mechanisms underlying POI development. Clinical picture of this disease is mainly manifested by oligo- and amenorrhea as well as genitourinary menopausal syndrome (GUMS). Special attention is paid to a link between such clinical signs and psychosocial discomfort not being a life-threatening condition but still able to markedly lower quality of woman’s life and considered as a comorbidity with type 2 diabetes mellitus, osteoporosis and cardiovascular diseases. Hormone replacement therapy (HRT) serves as the first-line therapeutic approach for treating POI, which is performed according to the principles similar to those used to perform menopausal hormone therapy (MHT) in case of natural menopause that should be continued until reaching at least the average age for the onset of menopause. Topical estriol therapy eliminates GUMS symptoms, which in turn positively affects sexual function and woman’s psychosocial status and contributes to improved quality of life. The data from recent studies examining topical estriol therapy in POI demonstrated high efficacy and safety. Finally, we also discuss diverse strategies to support reproductive function in women with POI.https://www.gynecology.su/jour/article/view/781premature ovarian insufficiencypoigenitourinary menopausal syndromegumsquality of lifepsychosocial discomforthormone replacement therapyhrtmenopausal hormone therapymhtestriolreproductive function |
| spellingShingle | D. V. Blinov P. L. Hasan A. N. Mnatsakanyan D. I. Korabelnikov A. T. Safarov N. V. Pavlova N. S. Zakharova D. A. Ponomarev D. A. Petrenko Early menopause and premature ovarian insufficiency: problems and perspectives Акушерство, гинекология и репродукция premature ovarian insufficiency poi genitourinary menopausal syndrome gums quality of life psychosocial discomfort hormone replacement therapy hrt menopausal hormone therapy mht estriol reproductive function |
| title | Early menopause and premature ovarian insufficiency: problems and perspectives |
| title_full | Early menopause and premature ovarian insufficiency: problems and perspectives |
| title_fullStr | Early menopause and premature ovarian insufficiency: problems and perspectives |
| title_full_unstemmed | Early menopause and premature ovarian insufficiency: problems and perspectives |
| title_short | Early menopause and premature ovarian insufficiency: problems and perspectives |
| title_sort | early menopause and premature ovarian insufficiency problems and perspectives |
| topic | premature ovarian insufficiency poi genitourinary menopausal syndrome gums quality of life psychosocial discomfort hormone replacement therapy hrt menopausal hormone therapy mht estriol reproductive function |
| url | https://www.gynecology.su/jour/article/view/781 |
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