Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications
Integrating traditional herbal extracts into modern biomaterials offers a promising route for advanced wound care. A standardized <i>Buddleja globosa</i> Hope extract (BG-126), recognized for its therapeutic value, was incorporated into polymeric scaffolds with variable composition to ex...
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2025-05-01
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| author | Ricardo Ceriani Daniel A. Cherif-Pino Pamela Pérez-Basáez Marcela Escobar Patricio Leyton Caroline R. Weinstein-Oppenheimer Daniel F. Moraga-Espinoza Tania F. Bahamondez-Canas |
| author_facet | Ricardo Ceriani Daniel A. Cherif-Pino Pamela Pérez-Basáez Marcela Escobar Patricio Leyton Caroline R. Weinstein-Oppenheimer Daniel F. Moraga-Espinoza Tania F. Bahamondez-Canas |
| author_sort | Ricardo Ceriani |
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| description | Integrating traditional herbal extracts into modern biomaterials offers a promising route for advanced wound care. A standardized <i>Buddleja globosa</i> Hope extract (BG-126), recognized for its therapeutic value, was incorporated into polymeric scaffolds with variable composition to explore their potential in promoting wound healing and controlling infections. This work aimed to identify the polymeric composition of a scaffold with BG-126 that maximizes its compatibility and antimicrobial properties. Scaffolds were developed by lyophilization using a Box–Behnken design (BBD) with chitosan, hyaluronic acid, and gelatin content as study factors. Thirteen scaffold formulations were tested for their antimicrobial activity against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, including biofilm forms, as well as for their biocompatibility with normal human fibroblasts. Structural and physical properties, such as the moisture content and swelling capacity, were evaluated. The best-performing scaffold was analyzed using Raman spectroscopy. The chitosan content was strongly associated with antimicrobial efficacy, while gelatin enhanced fibroblast compatibility (R<sup>2</sup> ≥ 0.9). No correlations were identified between the polymeric content and biofilm inhibition or physical properties. BG-126-loaded scaffolds reduced planktonic and biofilm proliferation and improved fibroblast compatibility compared to the control scaffold (without BG-126). The results support the rational design of botanical-loaded scaffolds with targeted properties for wound healing. |
| format | Article |
| id | doaj-art-8fcc7d2f5ebe490387df2ad35668ea56 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-05-01 |
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| series | Molecules |
| spelling | doaj-art-8fcc7d2f5ebe490387df2ad35668ea562025-08-20T03:46:50ZengMDPI AGMolecules1420-30492025-05-013011242810.3390/molecules30112428Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing ApplicationsRicardo Ceriani0Daniel A. Cherif-Pino1Pamela Pérez-Basáez2Marcela Escobar3Patricio Leyton4Caroline R. Weinstein-Oppenheimer5Daniel F. Moraga-Espinoza6Tania F. Bahamondez-Canas7Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileEscuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileEscuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileEscuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileInstituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaiso 2340000, ChileEscuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileEscuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileEscuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Valparaiso 2340000, ChileIntegrating traditional herbal extracts into modern biomaterials offers a promising route for advanced wound care. A standardized <i>Buddleja globosa</i> Hope extract (BG-126), recognized for its therapeutic value, was incorporated into polymeric scaffolds with variable composition to explore their potential in promoting wound healing and controlling infections. This work aimed to identify the polymeric composition of a scaffold with BG-126 that maximizes its compatibility and antimicrobial properties. Scaffolds were developed by lyophilization using a Box–Behnken design (BBD) with chitosan, hyaluronic acid, and gelatin content as study factors. Thirteen scaffold formulations were tested for their antimicrobial activity against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, including biofilm forms, as well as for their biocompatibility with normal human fibroblasts. Structural and physical properties, such as the moisture content and swelling capacity, were evaluated. The best-performing scaffold was analyzed using Raman spectroscopy. The chitosan content was strongly associated with antimicrobial efficacy, while gelatin enhanced fibroblast compatibility (R<sup>2</sup> ≥ 0.9). No correlations were identified between the polymeric content and biofilm inhibition or physical properties. BG-126-loaded scaffolds reduced planktonic and biofilm proliferation and improved fibroblast compatibility compared to the control scaffold (without BG-126). The results support the rational design of botanical-loaded scaffolds with targeted properties for wound healing.https://www.mdpi.com/1420-3049/30/11/2428scaffoldsnatural extractwound healingantimicrobialbiocompatibility |
| spellingShingle | Ricardo Ceriani Daniel A. Cherif-Pino Pamela Pérez-Basáez Marcela Escobar Patricio Leyton Caroline R. Weinstein-Oppenheimer Daniel F. Moraga-Espinoza Tania F. Bahamondez-Canas Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications Molecules scaffolds natural extract wound healing antimicrobial biocompatibility |
| title | Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications |
| title_full | Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications |
| title_fullStr | Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications |
| title_full_unstemmed | Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications |
| title_short | Tailoring Polymeric Scaffolds with <i>Buddleja globosa</i> Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications |
| title_sort | tailoring polymeric scaffolds with i buddleja globosa i extract for dual antimicrobial and biocompatible wound healing applications |
| topic | scaffolds natural extract wound healing antimicrobial biocompatibility |
| url | https://www.mdpi.com/1420-3049/30/11/2428 |
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