Effectiveness and safety of a fixed, low-dose perindopril/ indapamide combination in patients with arterial hypertension: real-world clinical practice data (STRATEGYA, a multi-center, open, prospective study)
Aim. To study the role of fixed, low-dose perindopril/indapamide combination in the treatment of patients with arterial hypertension (AH) and inadequate blood pressure (BP) control. Material and methods: In total, 1726 AH patients with inadequate BP control were divided into three subgroups: I – pat...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
1970-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1566 |
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| Summary: | Aim. To study the role of fixed, low-dose perindopril/indapamide combination in the treatment of patients with arterial hypertension (AH) and inadequate blood pressure (BP) control. Material and methods: In total, 1726 AH patients with inadequate BP control were divided into three subgroups: I – patients with first-diagnosed AH (n=598, 37%), II – patients whose previously taken antihypertensive agent was changed to Noliprel® (n=582, 35%), and III – patients receiving previous antihypertensive therapy and Noliprel® (n=458, 28%). Subgroups were formed by the doctors. All participants were administered Noliprel®; the dose was doubled if one-month treatment was ineffective (Noliprel® forte). Therapy effectiveness was assessed by office BP measurement at baseline, after 1 and 4 months of the treatment. At 14 clinical centers (n=280), more detailed investigation of treatment safety and effectiveness was performed, including 24-hour BP monitoring (BPM) and blood biochemical analysis at visits 1 and 3. Results. After 4 months of treatment, in the whole group and in subgroups, systolic and diastolic BP levels were significantly reduced, according to office measurement and 24-hour BPM. Noliprel®/Noliprel® forte therapy was safe and well tolerated by the patients. Conclusion. Fixed combination of antihypertensives (Noliprel®/Noliprel® forte) effectively and safely reduced BP in patients with uncontrolled AH. Noliprel® therapy was associated with target BP level achievement not only in first-diagnosed AH, but also in case of ineffective previous antihypertensive treatment. |
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| ISSN: | 1728-8800 2619-0125 |