The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis
Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.
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| Main Authors: | Pietro Di Fazio, Regine Schneider-Stock, Daniel Neureiter, Kinya Okamoto, Till Wissniowski, Susanne Gahr, Karl Quint, Matthias Meissnitzer, Beate Alinger, Roberta Montalbano, Gabriele Sass, Bernd Hohenstein, Eckhart G. Hahn, Matthias Ocker |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2010-0511 |
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