The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis
Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2010-0511 |
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| author | Pietro Di Fazio Regine Schneider-Stock Daniel Neureiter Kinya Okamoto Till Wissniowski Susanne Gahr Karl Quint Matthias Meissnitzer Beate Alinger Roberta Montalbano Gabriele Sass Bernd Hohenstein Eckhart G. Hahn Matthias Ocker |
| author_facet | Pietro Di Fazio Regine Schneider-Stock Daniel Neureiter Kinya Okamoto Till Wissniowski Susanne Gahr Karl Quint Matthias Meissnitzer Beate Alinger Roberta Montalbano Gabriele Sass Bernd Hohenstein Eckhart G. Hahn Matthias Ocker |
| author_sort | Pietro Di Fazio |
| collection | DOAJ |
| description | Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced. |
| format | Article |
| id | doaj-art-8fc91e5f84eb41f499cd926a158c4597 |
| institution | OA Journals |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-8fc91e5f84eb41f499cd926a158c45972025-08-20T02:09:29ZengWileyCellular Oncology1570-58701875-86062010-01-0132428530010.3233/CLO-2010-0511The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of ApoptosisPietro Di Fazio0Regine Schneider-Stock1Daniel Neureiter2Kinya Okamoto3Till Wissniowski4Susanne Gahr5Karl Quint6Matthias Meissnitzer7Beate Alinger8Roberta Montalbano9Gabriele Sass10Bernd Hohenstein11Eckhart G. Hahn12Matthias Ocker13Department of Medicine 1, University Hospital Erlangen, Erlangen, GermanyDepartment of Pathology, University Hospital Erlangen, Erlangen, GermanyInstitute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, AustriaDepartment of Medicine 1, University Hospital Erlangen, Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Erlangen, GermanyInstitute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, AustriaInstitute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, AustriaDipartimento di Scienze Biochimiche, Universita di Palermo, Policlinico, Palermo, ItalyDivision of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, GermanyDepartment of Medicine 4, University Hospital Erlangen, Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Erlangen, GermanyDepartment of Medicine 1, University Hospital Erlangen, Erlangen, GermanyInhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.http://dx.doi.org/10.3233/CLO-2010-0511 |
| spellingShingle | Pietro Di Fazio Regine Schneider-Stock Daniel Neureiter Kinya Okamoto Till Wissniowski Susanne Gahr Karl Quint Matthias Meissnitzer Beate Alinger Roberta Montalbano Gabriele Sass Bernd Hohenstein Eckhart G. Hahn Matthias Ocker The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis Cellular Oncology |
| title | The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis |
| title_full | The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis |
| title_fullStr | The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis |
| title_full_unstemmed | The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis |
| title_short | The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis |
| title_sort | pan deacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis |
| url | http://dx.doi.org/10.3233/CLO-2010-0511 |
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