The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis

The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis

Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.

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Bibliographic Details
Main Authors: Pietro Di Fazio, Regine Schneider-Stock, Daniel Neureiter, Kinya Okamoto, Till Wissniowski, Susanne Gahr, Karl Quint, Matthias Meissnitzer, Beate Alinger, Roberta Montalbano, Gabriele Sass, Bernd Hohenstein, Eckhart G. Hahn, Matthias Ocker
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2010-0511
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Summary:Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.
ISSN:1570-5870
1875-8606

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