Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses

Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses

Hypoxia, a prevalent characteristic of solid tumors, substantially impairs the efficacy of cancer treatments. However, there are no feasible clinical approaches for treating hypoxic tumors. Here, we develop metal-phenolic networks (CuGI) utilizing the natural glycolysis inhibitor (epigallocatechin g...

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Bibliographic Details
Main Authors: Jia Liu, Zuoyu Chen, Lixue Deng, Chundong Yao, Zhixin Zhou, Cheng Zhou, Yawen Bin, Miaodeng Liu, Liping Wang, Lin Wang, Zheng Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-05-01
Series:Bioactive Materials
Subjects:
Tumor hypoxia
Metal-organic networks
Cell metabolism
Reactive oxygen species
Cuproptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25000222
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