Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies
ABSTRACT Ferroptosis is a distinct form of iron‐dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, iron metabolism, lipid metabolism, various signaling pathways, and autophag...
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2025-03-01
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| Online Access: | https://doi.org/10.1002/mco2.70116 |
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| author | Dandan Guo Songhua Cai Lvdan Deng Wangting Xu Sentao Fu Yaling Lin Tong Jiang Qing Li Zhijun Shen Jian Zhang Peng Luo Bufu Tang Ling Wang |
| author_facet | Dandan Guo Songhua Cai Lvdan Deng Wangting Xu Sentao Fu Yaling Lin Tong Jiang Qing Li Zhijun Shen Jian Zhang Peng Luo Bufu Tang Ling Wang |
| author_sort | Dandan Guo |
| collection | DOAJ |
| description | ABSTRACT Ferroptosis is a distinct form of iron‐dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, iron metabolism, lipid metabolism, various signaling pathways, and autophagy, have been demonstrated to influence the induction and progression of ferroptosis. Recent investigations have elucidated that ferroptosis plays a crucial role in the pathogenesis of various pulmonary disorders, including lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, and asthma. Ferroptosis is increasingly recognized as a promising novel strategy for cancer treatment. Various immune cells within the tumor microenvironment, including CD8+ T cells, macrophages, regulatory T cells, natural killer cells, and dendritic cells, have been shown to induce ferroptosis in tumor cells and modulate the process through the regulation of iron and lipid metabolism pathways. Conversely, ferroptosis can reciprocally alter the metabolic environment, leading to the activation or inhibition of immune cell functions, thereby modulating immune responses. This paper reviews the molecular mechanism of ferroptosis and describes the tumor immune microenvironment, discusses the connection between ferroptosis and the tumor microenvironment in lung cancer and pulmonary diseases, and discusses the development prospect of their interaction in the treatment of lung cancer and pulmonary diseases. |
| format | Article |
| id | doaj-art-8fc0f254f89c46e2a25fbb8bfc82bf18 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-8fc0f254f89c46e2a25fbb8bfc82bf182025-08-20T03:40:28ZengWileyMedComm2688-26632025-03-0163n/an/a10.1002/mco2.70116Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic StrategiesDandan Guo0Songhua Cai1Lvdan Deng2Wangting Xu3Sentao Fu4Yaling Lin5Tong Jiang6Qing Li7Zhijun Shen8Jian Zhang9Peng Luo10Bufu Tang11Ling Wang12The Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaDepartment of Thoracic Surgery National Cancer Center National Clinical Research Center for Cancer Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen Guangdong ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaDepartment of Respiratory First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaThe Department of Oncology Zhujiang Hospital Southern Medical University Guangzhou Guangdong ChinaThe Department of Oncology Zhujiang Hospital Southern Medical University Guangzhou Guangdong ChinaDepartment of Radiation Oncology Zhongshan Hospital Fudan University Shanghai Shanghai ChinaThe Department of Oncology First Affiliated Hospital of Dalian Medical University Dalian Liaoning ChinaABSTRACT Ferroptosis is a distinct form of iron‐dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, iron metabolism, lipid metabolism, various signaling pathways, and autophagy, have been demonstrated to influence the induction and progression of ferroptosis. Recent investigations have elucidated that ferroptosis plays a crucial role in the pathogenesis of various pulmonary disorders, including lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, and asthma. Ferroptosis is increasingly recognized as a promising novel strategy for cancer treatment. Various immune cells within the tumor microenvironment, including CD8+ T cells, macrophages, regulatory T cells, natural killer cells, and dendritic cells, have been shown to induce ferroptosis in tumor cells and modulate the process through the regulation of iron and lipid metabolism pathways. Conversely, ferroptosis can reciprocally alter the metabolic environment, leading to the activation or inhibition of immune cell functions, thereby modulating immune responses. This paper reviews the molecular mechanism of ferroptosis and describes the tumor immune microenvironment, discusses the connection between ferroptosis and the tumor microenvironment in lung cancer and pulmonary diseases, and discusses the development prospect of their interaction in the treatment of lung cancer and pulmonary diseases.https://doi.org/10.1002/mco2.70116ferroptosisimmune microenvironmentlung cancermolecular mechanismspulmonary disease |
| spellingShingle | Dandan Guo Songhua Cai Lvdan Deng Wangting Xu Sentao Fu Yaling Lin Tong Jiang Qing Li Zhijun Shen Jian Zhang Peng Luo Bufu Tang Ling Wang Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies MedComm ferroptosis immune microenvironment lung cancer molecular mechanisms pulmonary disease |
| title | Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies |
| title_full | Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies |
| title_fullStr | Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies |
| title_full_unstemmed | Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies |
| title_short | Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies |
| title_sort | ferroptosis in pulmonary disease and lung cancer molecular mechanisms crosstalk regulation and therapeutic strategies |
| topic | ferroptosis immune microenvironment lung cancer molecular mechanisms pulmonary disease |
| url | https://doi.org/10.1002/mco2.70116 |
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