Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results)
Background. Identification of the prevalence of pollen and food allergen molecules sensitization in children (considering regional characteristics) is relevant and crucial for personalized preventive and treatment measures development. Objective. The aim of the study is — study the prevalence of pol...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2023-01-01
|
| Series: | Педиатрическая фармакология |
| Subjects: | |
| Online Access: | https://www.pedpharma.ru/jour/article/view/2215 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849394102181822464 |
|---|---|
| author | Julia G. Levina Vera G. Kalugina Leyla S. Namazova-Baranova Elena A. Vishneva Konstantin S. Volkov Kamilla E. Efendieva Anna A. Alekseeva Elena V. Kaytukovа |
| author_facet | Julia G. Levina Vera G. Kalugina Leyla S. Namazova-Baranova Elena A. Vishneva Konstantin S. Volkov Kamilla E. Efendieva Anna A. Alekseeva Elena V. Kaytukovа |
| author_sort | Julia G. Levina |
| collection | DOAJ |
| description | Background. Identification of the prevalence of pollen and food allergen molecules sensitization in children (considering regional characteristics) is relevant and crucial for personalized preventive and treatment measures development. Objective. The aim of the study is — study the prevalence of pollen and food allergen sensitization in children with different atopic phenotype variants. Methods. This cross-sectional study included 80 children aged from 4 months to 17 years 8 months with symptoms of allergic rhinitis, food allergy, atopic dermatitis living in the Moscow metropolitan area. All children were sensitized to 9 extracts of domestic, pollen and food allergens via the ImmunoCAP method, and molecular allergy diagnosis was carried out via the ImmunoCAP ISAC technology (n = 79). One patient with symptoms of allergic rhinitis during spring without any manifestations of cross-reactive food allergy received an unreadable result of ImmunoCAP ISAC. Results. The most common sensitization among all patients was to the birch pollen allergen extract — 65%, herd grass — 46%, common mugwort — 32%. The following sensitization to major allergens was most often detected according to molecular diagnosis: birch pollen Bet v 1 — 67%, herd grass Phl p 1 — 33% and Phl p 4 — 24%, and even less mugwort Art v 1 — 11%. The lowest sensitization was to the allergy component Amb a 1 of ambrosia — 8% of cases. Sensitization to wormwood pollen extract was revealed 2.5 times more often than to major components of this allergen. Spring allergic rhinitis was diagnosed in 45 children, and 27 of them had cross-reactive food allergy. Children with allergic rhinitis during the spring period (both with or without complaints on cross-reactive food allergy) most commonly had sensitization to the allergens components of hazelnut Cor a 1.0401 and apple Mal d 1, and least often to the component of the celery allergen Api g 1. Conclusion. Birch pollen is the most common primary allergen in children of the Moscow metropolitan area with allergy. Patients with spring allergic rhinitis despite the presence of cross-reactive food allergy usually have sensitization to the components of hazelnut and apple allergens. |
| format | Article |
| id | doaj-art-8fbf2b8a1d674d4194768883fbec05af |
| institution | Kabale University |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2023-01-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-8fbf2b8a1d674d4194768883fbec05af2025-08-20T03:40:10ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892023-01-0119539440310.15690/pf.v19i5.24641931Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results)Julia G. Levina0Vera G. Kalugina1Leyla S. Namazova-Baranova2Elena A. Vishneva3Konstantin S. Volkov4Kamilla E. Efendieva5Anna A. Alekseeva6Elena V. Kaytukovа7Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityBackground. Identification of the prevalence of pollen and food allergen molecules sensitization in children (considering regional characteristics) is relevant and crucial for personalized preventive and treatment measures development. Objective. The aim of the study is — study the prevalence of pollen and food allergen sensitization in children with different atopic phenotype variants. Methods. This cross-sectional study included 80 children aged from 4 months to 17 years 8 months with symptoms of allergic rhinitis, food allergy, atopic dermatitis living in the Moscow metropolitan area. All children were sensitized to 9 extracts of domestic, pollen and food allergens via the ImmunoCAP method, and molecular allergy diagnosis was carried out via the ImmunoCAP ISAC technology (n = 79). One patient with symptoms of allergic rhinitis during spring without any manifestations of cross-reactive food allergy received an unreadable result of ImmunoCAP ISAC. Results. The most common sensitization among all patients was to the birch pollen allergen extract — 65%, herd grass — 46%, common mugwort — 32%. The following sensitization to major allergens was most often detected according to molecular diagnosis: birch pollen Bet v 1 — 67%, herd grass Phl p 1 — 33% and Phl p 4 — 24%, and even less mugwort Art v 1 — 11%. The lowest sensitization was to the allergy component Amb a 1 of ambrosia — 8% of cases. Sensitization to wormwood pollen extract was revealed 2.5 times more often than to major components of this allergen. Spring allergic rhinitis was diagnosed in 45 children, and 27 of them had cross-reactive food allergy. Children with allergic rhinitis during the spring period (both with or without complaints on cross-reactive food allergy) most commonly had sensitization to the allergens components of hazelnut Cor a 1.0401 and apple Mal d 1, and least often to the component of the celery allergen Api g 1. Conclusion. Birch pollen is the most common primary allergen in children of the Moscow metropolitan area with allergy. Patients with spring allergic rhinitis despite the presence of cross-reactive food allergy usually have sensitization to the components of hazelnut and apple allergens.https://www.pedpharma.ru/jour/article/view/2215childrenallergic rhinitiscross-reactive food allergylatent sensitizationmolecular allergy diagnosis |
| spellingShingle | Julia G. Levina Vera G. Kalugina Leyla S. Namazova-Baranova Elena A. Vishneva Konstantin S. Volkov Kamilla E. Efendieva Anna A. Alekseeva Elena V. Kaytukovа Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results) Педиатрическая фармакология children allergic rhinitis cross-reactive food allergy latent sensitization molecular allergy diagnosis |
| title | Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results) |
| title_full | Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results) |
| title_fullStr | Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results) |
| title_full_unstemmed | Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results) |
| title_short | Identification of Pollen and Food Sensitization Prevalence in Children with Different Atopic Phenotype Variants (Intermediate Study Results) |
| title_sort | identification of pollen and food sensitization prevalence in children with different atopic phenotype variants intermediate study results |
| topic | children allergic rhinitis cross-reactive food allergy latent sensitization molecular allergy diagnosis |
| url | https://www.pedpharma.ru/jour/article/view/2215 |
| work_keys_str_mv | AT juliaglevina identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT veragkalugina identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT leylasnamazovabaranova identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT elenaavishneva identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT konstantinsvolkov identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT kamillaeefendieva identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT annaaalekseeva identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults AT elenavkaytukova identificationofpollenandfoodsensitizationprevalenceinchildrenwithdifferentatopicphenotypevariantsintermediatestudyresults |