A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study
<b>Background</b>: Diabetic foot ulcers (DFUs) affect 25% of diabetes patients, with high risks of amputation (70%), recurrence (65% within 3–5 years), and mortality (50–70% at 5-years). Current treatments are limited by persistent inflammation, oxidative stress, and cost barriers. This...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/1999-4923/17/6/772 |
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| author | Thamis Fernandes Santana Gomes Natália Carvalho Guimarães Ludmilla Pinto Guiotti Cintra Abreu Gabriella de Oliveira Silva Vitória Regina Pereira da Silva Franciéle de Matos da Silva Fabiane Hiratsuka Veiga-Souza Paulo Eduardo Narcizo de Souza Mário Fabrício Fleury Rosa Graziella Anselmo Joanitti Suélia de Siqueira Rodrigues Fleury Rosa Marcella Lemos Brettas Carneiro |
| author_facet | Thamis Fernandes Santana Gomes Natália Carvalho Guimarães Ludmilla Pinto Guiotti Cintra Abreu Gabriella de Oliveira Silva Vitória Regina Pereira da Silva Franciéle de Matos da Silva Fabiane Hiratsuka Veiga-Souza Paulo Eduardo Narcizo de Souza Mário Fabrício Fleury Rosa Graziella Anselmo Joanitti Suélia de Siqueira Rodrigues Fleury Rosa Marcella Lemos Brettas Carneiro |
| author_sort | Thamis Fernandes Santana Gomes |
| collection | DOAJ |
| description | <b>Background</b>: Diabetic foot ulcers (DFUs) affect 25% of diabetes patients, with high risks of amputation (70%), recurrence (65% within 3–5 years), and mortality (50–70% at 5-years). Current treatments are limited by persistent inflammation, oxidative stress, and cost barriers. This study evaluates a bioactive dressing combining a natural latex-based (NLB) biomembrane (<i>Hevea brasiliensis</i>) with curcumin-loaded liposomes, exhibiting angiogenic and antimicrobial properties, and red LED (light-emitting diode) phototherapy (635–640 nm) to address these challenges. <b>Methods</b>: A pilot clinical trial randomized 15 DFU participants into three groups: Control (CG, <i>n</i> = 5, standard care); Experimental Group 1 (EG1, <i>n</i> = 5, NLB + LED, daily treatment); and Experimental Group 2 (EG2, <i>n</i> = 5, NLB-curcumin liposomes + LED, daily treatment). Outcomes included wound closure, inflammatory/oxidative markers, and therapy feasibility. Assessments at D0, D22, and D45 included hematological/biochemical profiling, reactive oxygen species (ROS), and wound area measures. <b>Results</b>: On day 45, GE2 showed an average ulcer contraction of 89.8%, while CG showed 32.8%, and GE1 showed 9.7%. Systemic ROS and biomarkers (C-reactive protein, leukocytes) showed no significant changes (<i>p</i> > 0.05), though transient inflammatory spikes occurred. The combined therapy (EG2) accelerated healing without direct biomarker correlations. <b>Conclusions</b>: These findings highlight the potential of this combined therapy as an accessible, cost-effective DFU treatment, warranting larger studies to optimize home-based protocols and elucidate mechanisms. |
| format | Article |
| id | doaj-art-8fbd8e95e5644099a489e0bd56cc29be |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-8fbd8e95e5644099a489e0bd56cc29be2025-08-20T02:21:49ZengMDPI AGPharmaceutics1999-49232025-06-0117677210.3390/pharmaceutics17060772A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical StudyThamis Fernandes Santana Gomes0Natália Carvalho Guimarães1Ludmilla Pinto Guiotti Cintra Abreu2Gabriella de Oliveira Silva3Vitória Regina Pereira da Silva4Franciéle de Matos da Silva5Fabiane Hiratsuka Veiga-Souza6Paulo Eduardo Narcizo de Souza7Mário Fabrício Fleury Rosa8Graziella Anselmo Joanitti9Suélia de Siqueira Rodrigues Fleury Rosa10Marcella Lemos Brettas Carneiro11Laboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Electron Paramagnetic Resonance, Institute of Physics, University of Brasilia, Brasilia 70910-900, DF, BrazilPostgraduate Program in Biomedical Engineering at Gama-FGA, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Brasilia 70910-900, DF, BrazilPostgraduate Program in Biomedical Engineering at Gama-FGA, University of Brasilia, Brasilia 70910-900, DF, BrazilLaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), University of Brasilia, Brasilia 70910-900, DF, Brazil<b>Background</b>: Diabetic foot ulcers (DFUs) affect 25% of diabetes patients, with high risks of amputation (70%), recurrence (65% within 3–5 years), and mortality (50–70% at 5-years). Current treatments are limited by persistent inflammation, oxidative stress, and cost barriers. This study evaluates a bioactive dressing combining a natural latex-based (NLB) biomembrane (<i>Hevea brasiliensis</i>) with curcumin-loaded liposomes, exhibiting angiogenic and antimicrobial properties, and red LED (light-emitting diode) phototherapy (635–640 nm) to address these challenges. <b>Methods</b>: A pilot clinical trial randomized 15 DFU participants into three groups: Control (CG, <i>n</i> = 5, standard care); Experimental Group 1 (EG1, <i>n</i> = 5, NLB + LED, daily treatment); and Experimental Group 2 (EG2, <i>n</i> = 5, NLB-curcumin liposomes + LED, daily treatment). Outcomes included wound closure, inflammatory/oxidative markers, and therapy feasibility. Assessments at D0, D22, and D45 included hematological/biochemical profiling, reactive oxygen species (ROS), and wound area measures. <b>Results</b>: On day 45, GE2 showed an average ulcer contraction of 89.8%, while CG showed 32.8%, and GE1 showed 9.7%. Systemic ROS and biomarkers (C-reactive protein, leukocytes) showed no significant changes (<i>p</i> > 0.05), though transient inflammatory spikes occurred. The combined therapy (EG2) accelerated healing without direct biomarker correlations. <b>Conclusions</b>: These findings highlight the potential of this combined therapy as an accessible, cost-effective DFU treatment, warranting larger studies to optimize home-based protocols and elucidate mechanisms.https://www.mdpi.com/1999-4923/17/6/772curcuminnatural latex biomembranewound healingulcersoxidative stressclinical assay |
| spellingShingle | Thamis Fernandes Santana Gomes Natália Carvalho Guimarães Ludmilla Pinto Guiotti Cintra Abreu Gabriella de Oliveira Silva Vitória Regina Pereira da Silva Franciéle de Matos da Silva Fabiane Hiratsuka Veiga-Souza Paulo Eduardo Narcizo de Souza Mário Fabrício Fleury Rosa Graziella Anselmo Joanitti Suélia de Siqueira Rodrigues Fleury Rosa Marcella Lemos Brettas Carneiro A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study Pharmaceutics curcumin natural latex biomembrane wound healing ulcers oxidative stress clinical assay |
| title | A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study |
| title_full | A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study |
| title_fullStr | A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study |
| title_full_unstemmed | A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study |
| title_short | A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study |
| title_sort | natural latex based smart dressing for curcumin delivery combined with led phototherapy in diabetic foot ulcers a pilot clinical study |
| topic | curcumin natural latex biomembrane wound healing ulcers oxidative stress clinical assay |
| url | https://www.mdpi.com/1999-4923/17/6/772 |
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