Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.
Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently proliferate to form a ductal tree filling the stromal compartment, and which can p...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2006-08-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020112&type=printable |
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| _version_ | 1850240138741809152 |
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| author | Beatrice Howard Alan Ashworth |
| author_facet | Beatrice Howard Alan Ashworth |
| author_sort | Beatrice Howard |
| collection | DOAJ |
| description | Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently proliferate to form a ductal tree filling the stromal compartment, and which can produce milk upon terminal differentiation after birth. Subsequently, these structures can be remodelled and returned to a basal state after weaning before regenerating in future pregnancies. The plasticity of the mammary epithelial cell, and its responsiveness to hormone receptors, facilitates this amazing biological feat, but aberrant signalling may also result in unintended consequences in the form of frequent malignancies. Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis. |
| format | Article |
| id | doaj-art-8fb96714d04c44c4bcb84a0ba23da0d9 |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2006-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-8fb96714d04c44c4bcb84a0ba23da0d92025-08-20T02:00:55ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042006-08-0128e11210.1371/journal.pgen.0020112Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.Beatrice HowardAlan AshworthSpecification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently proliferate to form a ductal tree filling the stromal compartment, and which can produce milk upon terminal differentiation after birth. Subsequently, these structures can be remodelled and returned to a basal state after weaning before regenerating in future pregnancies. The plasticity of the mammary epithelial cell, and its responsiveness to hormone receptors, facilitates this amazing biological feat, but aberrant signalling may also result in unintended consequences in the form of frequent malignancies. Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020112&type=printable |
| spellingShingle | Beatrice Howard Alan Ashworth Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. PLoS Genetics |
| title | Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. |
| title_full | Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. |
| title_fullStr | Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. |
| title_full_unstemmed | Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. |
| title_short | Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. |
| title_sort | signalling pathways implicated in early mammary gland morphogenesis and breast cancer |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0020112&type=printable |
| work_keys_str_mv | AT beatricehoward signallingpathwaysimplicatedinearlymammaryglandmorphogenesisandbreastcancer AT alanashworth signallingpathwaysimplicatedinearlymammaryglandmorphogenesisandbreastcancer |