The Role of Regulatory B Lymphocytes in Allergic Diseases
Purpose of review: Regulatory B cells (Bregs) are a key component in the regulation of the immune system. Their immunosuppressive function, which includes limiting the inflammatory cascade, occurs through interactions with other immune cells and the secretion of cytokines, primarily IL-10. As knowle...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2227-9059/12/12/2721 |
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| author | Agnieszka Lipińska-Opałka Michalina Leszczyńska-Pilich Agata Będzichowska Agata Tomaszewska Agnieszka Rustecka Bolesław Kalicki |
| author_facet | Agnieszka Lipińska-Opałka Michalina Leszczyńska-Pilich Agata Będzichowska Agata Tomaszewska Agnieszka Rustecka Bolesław Kalicki |
| author_sort | Agnieszka Lipińska-Opałka |
| collection | DOAJ |
| description | Purpose of review: Regulatory B cells (Bregs) are a key component in the regulation of the immune system. Their immunosuppressive function, which includes limiting the inflammatory cascade, occurs through interactions with other immune cells and the secretion of cytokines, primarily IL-10. As knowledge about B cells continues to expand, their diversity is becoming more recognized, with many subpopulations identified in both human and animal models. However, identifying specific transcription factors or markers that could definitively distinguish regulatory B cells remains a challenge. This review summarizes recent findings on the role of B regulatory cells in allergic diseases. Recent findings: In patients with bronchial asthma, atopic dermatitis, and food allergies, the number of regulatory B cells is reduced, and disease severity is inversely proportional to the quantity of these cells. Furthermore, in patients with atopic dermatitis, the ability of regulatory B cells to produce IL-10 in response to IL-6 stimulation is diminished. However, allergen immunotherapy has been shown to induce the formation of regulatory T cells as well as regulatory B cells. Summary: The success of future therapies based on B cells may depend on deepening our current understanding of their phenotypes, induction, differentiation, and function. Research in these areas is essential for understanding the mechanisms regulating Breg activity and for developing potential targeted therapies in the treatment of allergic diseases. |
| format | Article |
| id | doaj-art-8fb925f4dd37451a8fc048ba7ba867db |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-8fb925f4dd37451a8fc048ba7ba867db2025-08-20T02:53:37ZengMDPI AGBiomedicines2227-90592024-11-011212272110.3390/biomedicines12122721The Role of Regulatory B Lymphocytes in Allergic DiseasesAgnieszka Lipińska-Opałka0Michalina Leszczyńska-Pilich1Agata Będzichowska2Agata Tomaszewska3Agnieszka Rustecka4Bolesław Kalicki5Faculty of Medicine, University of Warsaw, 02-089 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine–National Research Institute, 01-141 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine–National Research Institute, 01-141 Warsaw, PolandFaculty of Medicine, University of Warsaw, 02-089 Warsaw, PolandDepartment of Pediatrics, Nephrology and Allergology, Military Institute of Medicine–National Research Institute, 01-141 Warsaw, PolandFaculty of Medicine, University of Warsaw, 02-089 Warsaw, PolandPurpose of review: Regulatory B cells (Bregs) are a key component in the regulation of the immune system. Their immunosuppressive function, which includes limiting the inflammatory cascade, occurs through interactions with other immune cells and the secretion of cytokines, primarily IL-10. As knowledge about B cells continues to expand, their diversity is becoming more recognized, with many subpopulations identified in both human and animal models. However, identifying specific transcription factors or markers that could definitively distinguish regulatory B cells remains a challenge. This review summarizes recent findings on the role of B regulatory cells in allergic diseases. Recent findings: In patients with bronchial asthma, atopic dermatitis, and food allergies, the number of regulatory B cells is reduced, and disease severity is inversely proportional to the quantity of these cells. Furthermore, in patients with atopic dermatitis, the ability of regulatory B cells to produce IL-10 in response to IL-6 stimulation is diminished. However, allergen immunotherapy has been shown to induce the formation of regulatory T cells as well as regulatory B cells. Summary: The success of future therapies based on B cells may depend on deepening our current understanding of their phenotypes, induction, differentiation, and function. Research in these areas is essential for understanding the mechanisms regulating Breg activity and for developing potential targeted therapies in the treatment of allergic diseases.https://www.mdpi.com/2227-9059/12/12/2721regulatory B cellsimmune systemasthmaatopic dermatitisallergic rhinitisfood allergy |
| spellingShingle | Agnieszka Lipińska-Opałka Michalina Leszczyńska-Pilich Agata Będzichowska Agata Tomaszewska Agnieszka Rustecka Bolesław Kalicki The Role of Regulatory B Lymphocytes in Allergic Diseases Biomedicines regulatory B cells immune system asthma atopic dermatitis allergic rhinitis food allergy |
| title | The Role of Regulatory B Lymphocytes in Allergic Diseases |
| title_full | The Role of Regulatory B Lymphocytes in Allergic Diseases |
| title_fullStr | The Role of Regulatory B Lymphocytes in Allergic Diseases |
| title_full_unstemmed | The Role of Regulatory B Lymphocytes in Allergic Diseases |
| title_short | The Role of Regulatory B Lymphocytes in Allergic Diseases |
| title_sort | role of regulatory b lymphocytes in allergic diseases |
| topic | regulatory B cells immune system asthma atopic dermatitis allergic rhinitis food allergy |
| url | https://www.mdpi.com/2227-9059/12/12/2721 |
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