Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations
Idiopathic nephrotic syndrome (INS) and other pediatric kidney diseases represent significant challenges due to their complex pathogenesis, often involving dysregulated immune responses and renal injury. Biologic therapies, defined as targeted treatments derived from living organisms, have gained tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Biologics |
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| Online Access: | https://www.mdpi.com/2673-8449/5/1/4 |
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| author | Matjaž Kopač |
| author_facet | Matjaž Kopač |
| author_sort | Matjaž Kopač |
| collection | DOAJ |
| description | Idiopathic nephrotic syndrome (INS) and other pediatric kidney diseases represent significant challenges due to their complex pathogenesis, often involving dysregulated immune responses and renal injury. Biologic therapies, defined as targeted treatments derived from living organisms, have gained traction in managing these conditions, offering a potential shift in therapeutic paradigms. This review examines the current and emerging role of biologics in treating pediatric kidney diseases, focusing on indications, contraindications, adverse effects, therapeutic positioning, and a comparison with alternative immunosuppressive treatments. |
| format | Article |
| id | doaj-art-8fb493a8b1bd46c6aac6a206b976f3aa |
| institution | DOAJ |
| issn | 2673-8449 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biologics |
| spelling | doaj-art-8fb493a8b1bd46c6aac6a206b976f3aa2025-08-20T02:42:45ZengMDPI AGBiologics2673-84492025-02-0151410.3390/biologics5010004Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special ConsiderationsMatjaž Kopač0Department of Nephrology, Division of Pediatrics, University Medical Centre Ljubljana, Bohoričeva 20, 1000 Ljubljana, SloveniaIdiopathic nephrotic syndrome (INS) and other pediatric kidney diseases represent significant challenges due to their complex pathogenesis, often involving dysregulated immune responses and renal injury. Biologic therapies, defined as targeted treatments derived from living organisms, have gained traction in managing these conditions, offering a potential shift in therapeutic paradigms. This review examines the current and emerging role of biologics in treating pediatric kidney diseases, focusing on indications, contraindications, adverse effects, therapeutic positioning, and a comparison with alternative immunosuppressive treatments.https://www.mdpi.com/2673-8449/5/1/4nephrotic syndromedysregulated immune responsesbiologic therapiesadverse effects |
| spellingShingle | Matjaž Kopač Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations Biologics nephrotic syndrome dysregulated immune responses biologic therapies adverse effects |
| title | Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations |
| title_full | Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations |
| title_fullStr | Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations |
| title_full_unstemmed | Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations |
| title_short | Biologics in Pediatric Idiopathic Nephrotic Syndrome and Other Kidney Diseases—General Principles and Special Considerations |
| title_sort | biologics in pediatric idiopathic nephrotic syndrome and other kidney diseases general principles and special considerations |
| topic | nephrotic syndrome dysregulated immune responses biologic therapies adverse effects |
| url | https://www.mdpi.com/2673-8449/5/1/4 |
| work_keys_str_mv | AT matjazkopac biologicsinpediatricidiopathicnephroticsyndromeandotherkidneydiseasesgeneralprinciplesandspecialconsiderations |