The natural course of cystic pancreatic neuroendocrine tumours in MEN1
Pancreatic neuroendocrine tumours (PanNETs) significantly impact life expectancy in multiple endocrine neoplasia type 1 (MEN1). Both solid and cystic pancreatic lesions are observed in MEN1, yet limited research has been focused on cystic lesions in MEN1. While solid PanNETs are generally considered...
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Bioscientifica
2025-02-01
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| Series: | Endocrine Oncology |
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| author | Eline N M van Vliembergen Carolina R C Pieterman Annenienke C van de Ven Arthur J A T Braat Gerlof D Valk Joanne M de Laat |
| author_facet | Eline N M van Vliembergen Carolina R C Pieterman Annenienke C van de Ven Arthur J A T Braat Gerlof D Valk Joanne M de Laat |
| author_sort | Eline N M van Vliembergen |
| collection | DOAJ |
| description | Pancreatic neuroendocrine tumours (PanNETs) significantly impact life expectancy in multiple endocrine neoplasia type 1 (MEN1). Both solid and cystic pancreatic lesions are observed in MEN1, yet limited research has been focused on cystic lesions in MEN1. While solid PanNETs are generally considered to have an indolent course, the natural course of cystic lesions remains unclear. This study aims to provide more insights into the natural course of cystic PanNETs in MEN1. Patients with MEN1 and radiologically suspected PanNETs, treated at UMC Utrecht and Radboudumc between 2010 and 2023, were included. In the first part, we examined the characteristics of patients with tumours visible on imaging scans. In the second part, we investigated outcomes of pathological examinations, following resection of these lesions. A total of 136 patients were included, comprising 60 men and 76 women. The median follow-up was 5.1 years. [68Ga]Ga-DOTATOC PET/CT scans showed that both cystic and solid lesions demonstrated [68Ga]Ga-DOTATOC PET/CT uptake. The median growth of cystic and solid PanNETs was similar. Pathological examination of 38 resected tumours confirmed that cystic lesions identified on imaging were indeed PanNETs. Cystic lesions had a median diameter of 26 mm at the time of resection, compared to 18 mm for solid lesions, with comparable Ki-67 indices and mitotic counts. We conclude that cystic and solid PanNETs in MEN1 patients appear to be morphological variations of the same entity, suggesting that similar management approaches should be considered. |
| format | Article |
| id | doaj-art-8fb361be252f474884a44a371f620b83 |
| institution | Kabale University |
| issn | 2634-4793 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Oncology |
| spelling | doaj-art-8fb361be252f474884a44a371f620b832025-02-09T11:59:45ZengBioscientificaEndocrine Oncology2634-47932025-02-015110.1530/EO-24-00501The natural course of cystic pancreatic neuroendocrine tumours in MEN1Eline N M van Vliembergen0Carolina R C Pieterman1Annenienke C van de Ven2Arthur J A T Braat3Gerlof D Valk4Joanne M de Laat5Department of Endocrine Oncology, University Medical Centre Utrecht, Utrecht, The NetherlandsDepartment of Endocrine Oncology, University Medical Centre Utrecht, Utrecht, The NetherlandsDepartment of Endocrinology, Radboud University Medical Centre, Nijmegen, The NetherlandsDepartment of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, The NetherlandsDepartment of Endocrine Oncology, University Medical Centre Utrecht, Utrecht, The NetherlandsDepartment of Endocrine Oncology, University Medical Centre Utrecht, Utrecht, The NetherlandsPancreatic neuroendocrine tumours (PanNETs) significantly impact life expectancy in multiple endocrine neoplasia type 1 (MEN1). Both solid and cystic pancreatic lesions are observed in MEN1, yet limited research has been focused on cystic lesions in MEN1. While solid PanNETs are generally considered to have an indolent course, the natural course of cystic lesions remains unclear. This study aims to provide more insights into the natural course of cystic PanNETs in MEN1. Patients with MEN1 and radiologically suspected PanNETs, treated at UMC Utrecht and Radboudumc between 2010 and 2023, were included. In the first part, we examined the characteristics of patients with tumours visible on imaging scans. In the second part, we investigated outcomes of pathological examinations, following resection of these lesions. A total of 136 patients were included, comprising 60 men and 76 women. The median follow-up was 5.1 years. [68Ga]Ga-DOTATOC PET/CT scans showed that both cystic and solid lesions demonstrated [68Ga]Ga-DOTATOC PET/CT uptake. The median growth of cystic and solid PanNETs was similar. Pathological examination of 38 resected tumours confirmed that cystic lesions identified on imaging were indeed PanNETs. Cystic lesions had a median diameter of 26 mm at the time of resection, compared to 18 mm for solid lesions, with comparable Ki-67 indices and mitotic counts. We conclude that cystic and solid PanNETs in MEN1 patients appear to be morphological variations of the same entity, suggesting that similar management approaches should be considered.https://eo.bioscientifica.com/view/journals/eo/5/1/EO-24-0050.xmlpancreatic neuroendocrine tumourmultiple endocrine neoplasia type 1cysticnatural coursehistopathology |
| spellingShingle | Eline N M van Vliembergen Carolina R C Pieterman Annenienke C van de Ven Arthur J A T Braat Gerlof D Valk Joanne M de Laat The natural course of cystic pancreatic neuroendocrine tumours in MEN1 Endocrine Oncology pancreatic neuroendocrine tumour multiple endocrine neoplasia type 1 cystic natural course histopathology |
| title | The natural course of cystic pancreatic neuroendocrine tumours in MEN1 |
| title_full | The natural course of cystic pancreatic neuroendocrine tumours in MEN1 |
| title_fullStr | The natural course of cystic pancreatic neuroendocrine tumours in MEN1 |
| title_full_unstemmed | The natural course of cystic pancreatic neuroendocrine tumours in MEN1 |
| title_short | The natural course of cystic pancreatic neuroendocrine tumours in MEN1 |
| title_sort | natural course of cystic pancreatic neuroendocrine tumours in men1 |
| topic | pancreatic neuroendocrine tumour multiple endocrine neoplasia type 1 cystic natural course histopathology |
| url | https://eo.bioscientifica.com/view/journals/eo/5/1/EO-24-0050.xml |
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