Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes
Abstract Electronic cigarettes (e-cigs) fundamentally differ from tobacco cigarettes in their generation of liquid-based aerosols. Investigating how e-cig aerosols behave when inhaled into the dynamic environment of the lung is important for understanding vaping-related exposure and toxicity. A vent...
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81066-x |
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| author | Liqiao Li Haoxuan Chen Yifang Zhu Airi Harui Michael D. Roth |
| author_facet | Liqiao Li Haoxuan Chen Yifang Zhu Airi Harui Michael D. Roth |
| author_sort | Liqiao Li |
| collection | DOAJ |
| description | Abstract Electronic cigarettes (e-cigs) fundamentally differ from tobacco cigarettes in their generation of liquid-based aerosols. Investigating how e-cig aerosols behave when inhaled into the dynamic environment of the lung is important for understanding vaping-related exposure and toxicity. A ventilated artificial lung model was developed to replicate the ventilatory and environmental features of the human lung and study their impact on the characteristics of inhaled e-cig aerosols from simulated vaping scenarios. Compared to static conditions, normal breathing decreased peak particle number concentrations (PNCs) and area under the curve (AUC) by 40% and 70%, respectively, and increased particle decay rates fourfold. However, even with ventilation, intrapulmonary PNC levels exceeded 2 × 106 particles/mL in a 4-puff vaping session. Both respiratory rate and tidal volume modulated e-cig aerosol exposure in a manner inversely proportional to minute ventilation. The modeled lung environment (37 °C, 88% relative humidity) also significantly altered particle size distributions by facilitating aerosol transformations such as hygroscopic growth, which further impacted e-cig aerosol exposure and particle removal. This work highlights the dynamic nature of intrapulmonary exposures and underscores the need to account for lung physiology and environmental factors when assessing inhaled e-cig aerosols. |
| format | Article |
| id | doaj-art-8fa9b4d92e40438095125ba41824ce22 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-8fa9b4d92e40438095125ba41824ce222025-01-05T12:26:42ZengNature PortfolioScientific Reports2045-23222024-12-0114111110.1038/s41598-024-81066-xVentilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettesLiqiao Li0Haoxuan Chen1Yifang Zhu2Airi Harui3Michael D. Roth4Department of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of CaliforniaDepartment of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of CaliforniaDepartment of Environmental Health Sciences, Jonathan and Karin Fielding School of Public Health, University of CaliforniaDivision of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine, University of CaliforniaDivision of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine, University of CaliforniaAbstract Electronic cigarettes (e-cigs) fundamentally differ from tobacco cigarettes in their generation of liquid-based aerosols. Investigating how e-cig aerosols behave when inhaled into the dynamic environment of the lung is important for understanding vaping-related exposure and toxicity. A ventilated artificial lung model was developed to replicate the ventilatory and environmental features of the human lung and study their impact on the characteristics of inhaled e-cig aerosols from simulated vaping scenarios. Compared to static conditions, normal breathing decreased peak particle number concentrations (PNCs) and area under the curve (AUC) by 40% and 70%, respectively, and increased particle decay rates fourfold. However, even with ventilation, intrapulmonary PNC levels exceeded 2 × 106 particles/mL in a 4-puff vaping session. Both respiratory rate and tidal volume modulated e-cig aerosol exposure in a manner inversely proportional to minute ventilation. The modeled lung environment (37 °C, 88% relative humidity) also significantly altered particle size distributions by facilitating aerosol transformations such as hygroscopic growth, which further impacted e-cig aerosol exposure and particle removal. This work highlights the dynamic nature of intrapulmonary exposures and underscores the need to account for lung physiology and environmental factors when assessing inhaled e-cig aerosols.https://doi.org/10.1038/s41598-024-81066-xArtificial lungInhalation exposureElectronic cigarettesAerosol transformation |
| spellingShingle | Liqiao Li Haoxuan Chen Yifang Zhu Airi Harui Michael D. Roth Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes Scientific Reports Artificial lung Inhalation exposure Electronic cigarettes Aerosol transformation |
| title | Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes |
| title_full | Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes |
| title_fullStr | Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes |
| title_full_unstemmed | Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes |
| title_short | Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes |
| title_sort | ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes |
| topic | Artificial lung Inhalation exposure Electronic cigarettes Aerosol transformation |
| url | https://doi.org/10.1038/s41598-024-81066-x |
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