Recent advances of lysine lactylation in prokaryotes and eukaryotes
Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling mol...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1510975/full |
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| author | Wenjuan Zhao Wenjuan Zhao Jiayi Xin Jiayi Xin Xin Yu Zhifang Li Nan Li |
| author_facet | Wenjuan Zhao Wenjuan Zhao Jiayi Xin Jiayi Xin Xin Yu Zhifang Li Nan Li |
| author_sort | Wenjuan Zhao |
| collection | DOAJ |
| description | Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. Unlike previous reviews focused primarily on eukaryotes, this review aims to provide a comprehensive summary of recent knowledge about lysine lactylation in prokaryotes and eukaryotes. The current identification and enrichment strategies for lysine lactylation are introduced, and the known readers, writers, and erasers of this modification are summarized. In addition, the physiological and pathological implications of lysine lactylation are reviewed for different organisms, especially in prokaryotic cells. Finally, we end with a discussion of the limitations of the studies so far and propose future directions for lysine lactylation investigations. |
| format | Article |
| id | doaj-art-8fa8bf1d236c477896300f955fc68741 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-8fa8bf1d236c477896300f955fc687412025-01-09T05:10:16ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-01-011110.3389/fmolb.2024.15109751510975Recent advances of lysine lactylation in prokaryotes and eukaryotesWenjuan Zhao0Wenjuan Zhao1Jiayi Xin2Jiayi Xin3Xin Yu4Zhifang Li5Nan Li6School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaSchool of life sciences, Henan University, Kaifeng, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaSchool of life sciences, Henan University, Kaifeng, ChinaShenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaLysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. Unlike previous reviews focused primarily on eukaryotes, this review aims to provide a comprehensive summary of recent knowledge about lysine lactylation in prokaryotes and eukaryotes. The current identification and enrichment strategies for lysine lactylation are introduced, and the known readers, writers, and erasers of this modification are summarized. In addition, the physiological and pathological implications of lysine lactylation are reviewed for different organisms, especially in prokaryotic cells. Finally, we end with a discussion of the limitations of the studies so far and propose future directions for lysine lactylation investigations.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1510975/fulllysine lactylationpost-translational modificationlactatecell metabolismtumorigenesis |
| spellingShingle | Wenjuan Zhao Wenjuan Zhao Jiayi Xin Jiayi Xin Xin Yu Zhifang Li Nan Li Recent advances of lysine lactylation in prokaryotes and eukaryotes Frontiers in Molecular Biosciences lysine lactylation post-translational modification lactate cell metabolism tumorigenesis |
| title | Recent advances of lysine lactylation in prokaryotes and eukaryotes |
| title_full | Recent advances of lysine lactylation in prokaryotes and eukaryotes |
| title_fullStr | Recent advances of lysine lactylation in prokaryotes and eukaryotes |
| title_full_unstemmed | Recent advances of lysine lactylation in prokaryotes and eukaryotes |
| title_short | Recent advances of lysine lactylation in prokaryotes and eukaryotes |
| title_sort | recent advances of lysine lactylation in prokaryotes and eukaryotes |
| topic | lysine lactylation post-translational modification lactate cell metabolism tumorigenesis |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1510975/full |
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