Enhancing venetoclax efficacy in leukemia through association with HDAC inhibitors

Enhancing venetoclax efficacy in leukemia through association with HDAC inhibitors

Abstract Epigenetic modifications significantly influence gene expression and play crucial roles in various biological processes, including carcinogenesis. This study investigates the effects of novel purine-benzohydroxamate compounds, particularly 4  f, as hybrid kinase/histone deacetylase (HDAC) i...

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Main Authors: Jorge Antonio Elias Godoy Carlos, Mauricio Temotheo Tavares, Keli Lima, Larissa Costa de Almeida, Karoline de Barros Waitman, Leticia Veras Costa-Lotufo, Roberto Parise-Filho, João Agostinho Machado-Neto
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02446-4
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