Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study
Abstract Background Metabolic syndrome (MetS) is a known contributor to increased cardiovascular risk and all-cause mortality. Recent literatures suggested that higher hemoglobin (Hb) levels were associated with Mets, left ventricular (LV) dysfunction and adverse events in general population. This s...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-025-02664-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850057371580104704 |
|---|---|
| author | Xue Li Shi-Qin Yu Zhi-Gang Yang Bi-Yue Hu Ke Shi Jing Wang Xue-Ming Li Ge Zhang Wen-Rong Li Rong Xu Yuan Li |
| author_facet | Xue Li Shi-Qin Yu Zhi-Gang Yang Bi-Yue Hu Ke Shi Jing Wang Xue-Ming Li Ge Zhang Wen-Rong Li Rong Xu Yuan Li |
| author_sort | Xue Li |
| collection | DOAJ |
| description | Abstract Background Metabolic syndrome (MetS) is a known contributor to increased cardiovascular risk and all-cause mortality. Recent literatures suggested that higher hemoglobin (Hb) levels were associated with Mets, left ventricular (LV) dysfunction and adverse events in general population. This study aimed to assess the associations between Hb levels and LV global strains in patients with MetS. Methods A retrospective analysis included 254 patients with MetS and 78 sex-, age-, and Hb-matched controls. The MetS patients were stratified into five groups based on Hb levels: anemia, low-normal Hb, moderate-normal Hb, high-normal Hb, and high Hb. LV global radial, circumferential, and longitudinal strains (LVGRS, LVGCS, and LVGLS, respectively) were measured using the cardiac magnetic resonance feature tracking technique. Associations between Hb levels and LV global strains were evaluated using multiple linear regression, restricted cubic spline (RCS), and subgroup analyses. Results After full adjustment, the LV global strains from three directions in the high Hb groups (LVGRS: β = − 4.943, 95% CI − 7.673 to − 2.213; LVGCS: β = − 2.341, 95% CI − 3.608 to − 1.074; LVGLS: β = −2.797, 95% CI − 4.049 to − 1.546, all p < 0.05) were significantly reduced than those in their respective moderate-normal Hb groups. Full adjusted RCS plots revealed inverted L-shaped associations between Hb levels and LV global strains, with significant reductions observed above 143 g/L (all p for nonlinearity < 0.05). Subgroup analyses indicated that the associations were more pronounced in MetS patients with obesity (LVGRS: β = − 0.005 [95% CI − 0.087 to 0.097] versus −0.087 [95% CI − 0.145 to − 0.030]; LVGCS: β = −0.006 [95% CI − 0.045 to 0.034] versus −0.048 [95% CI − 0.075 to − 0.021]; LVGLS: β = −0.011 [95% CI − 0.053 to 0.032] versus −0.063 [95% CI − 0.089 to − 0.036] for non-obese and obese patients; all p for interaction < 0.05). Conclusions Higher Hb levels are significantly associated with more severe LV dysfunction in MetS patients, particularly in those with obesity. Targeted monitoring and management of higher Hb levels in MetS patients may help mitigate further deterioration of cardiac function. |
| format | Article |
| id | doaj-art-8fa20f011dc341908f9b7df319e00468 |
| institution | DOAJ |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-8fa20f011dc341908f9b7df319e004682025-08-20T02:51:27ZengBMCCardiovascular Diabetology1475-28402025-03-0124111110.1186/s12933-025-02664-1Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking studyXue Li0Shi-Qin Yu1Zhi-Gang Yang2Bi-Yue Hu3Ke Shi4Jing Wang5Xue-Ming Li6Ge Zhang7Wen-Rong Li8Rong Xu9Yuan Li10Department of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityAbstract Background Metabolic syndrome (MetS) is a known contributor to increased cardiovascular risk and all-cause mortality. Recent literatures suggested that higher hemoglobin (Hb) levels were associated with Mets, left ventricular (LV) dysfunction and adverse events in general population. This study aimed to assess the associations between Hb levels and LV global strains in patients with MetS. Methods A retrospective analysis included 254 patients with MetS and 78 sex-, age-, and Hb-matched controls. The MetS patients were stratified into five groups based on Hb levels: anemia, low-normal Hb, moderate-normal Hb, high-normal Hb, and high Hb. LV global radial, circumferential, and longitudinal strains (LVGRS, LVGCS, and LVGLS, respectively) were measured using the cardiac magnetic resonance feature tracking technique. Associations between Hb levels and LV global strains were evaluated using multiple linear regression, restricted cubic spline (RCS), and subgroup analyses. Results After full adjustment, the LV global strains from three directions in the high Hb groups (LVGRS: β = − 4.943, 95% CI − 7.673 to − 2.213; LVGCS: β = − 2.341, 95% CI − 3.608 to − 1.074; LVGLS: β = −2.797, 95% CI − 4.049 to − 1.546, all p < 0.05) were significantly reduced than those in their respective moderate-normal Hb groups. Full adjusted RCS plots revealed inverted L-shaped associations between Hb levels and LV global strains, with significant reductions observed above 143 g/L (all p for nonlinearity < 0.05). Subgroup analyses indicated that the associations were more pronounced in MetS patients with obesity (LVGRS: β = − 0.005 [95% CI − 0.087 to 0.097] versus −0.087 [95% CI − 0.145 to − 0.030]; LVGCS: β = −0.006 [95% CI − 0.045 to 0.034] versus −0.048 [95% CI − 0.075 to − 0.021]; LVGLS: β = −0.011 [95% CI − 0.053 to 0.032] versus −0.063 [95% CI − 0.089 to − 0.036] for non-obese and obese patients; all p for interaction < 0.05). Conclusions Higher Hb levels are significantly associated with more severe LV dysfunction in MetS patients, particularly in those with obesity. Targeted monitoring and management of higher Hb levels in MetS patients may help mitigate further deterioration of cardiac function.https://doi.org/10.1186/s12933-025-02664-1Cardiac magnetic resonanceHemoglobin levelsLeft ventricular strainMetabolic syndromeObesity |
| spellingShingle | Xue Li Shi-Qin Yu Zhi-Gang Yang Bi-Yue Hu Ke Shi Jing Wang Xue-Ming Li Ge Zhang Wen-Rong Li Rong Xu Yuan Li Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study Cardiovascular Diabetology Cardiac magnetic resonance Hemoglobin levels Left ventricular strain Metabolic syndrome Obesity |
| title | Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study |
| title_full | Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study |
| title_fullStr | Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study |
| title_full_unstemmed | Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study |
| title_short | Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study |
| title_sort | higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome a 3 0 t cmr feature tracking study |
| topic | Cardiac magnetic resonance Hemoglobin levels Left ventricular strain Metabolic syndrome Obesity |
| url | https://doi.org/10.1186/s12933-025-02664-1 |
| work_keys_str_mv | AT xueli higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT shiqinyu higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT zhigangyang higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT biyuehu higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT keshi higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT jingwang higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT xuemingli higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT gezhang higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT wenrongli higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT rongxu higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy AT yuanli higherhemoglobinlevelsareassociatedwithimpairedleftventricularglobalstrainsinmetabolicsyndromea30tcmrfeaturetrackingstudy |