Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors
Background/Aims. Hemodialysis patients have a higher risk of hepatitis C compared to the general population. The burden of hepatitis C infection among hemodialysis patients is substantial and was estimated to rise constantly. This study is aimed at determining the frequency of HCV seroconversion and...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/8109977 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850211756514738176 |
|---|---|
| author | Ni Wayan Wina Dharmesti I Dewa Nyoman Wibawa Yenny Kandarini |
| author_facet | Ni Wayan Wina Dharmesti I Dewa Nyoman Wibawa Yenny Kandarini |
| author_sort | Ni Wayan Wina Dharmesti |
| collection | DOAJ |
| description | Background/Aims. Hemodialysis patients have a higher risk of hepatitis C compared to the general population. The burden of hepatitis C infection among hemodialysis patients is substantial and was estimated to rise constantly. This study is aimed at determining the frequency of HCV seroconversion and associated risk factors among hemodialysis patients in our unit. Methods. An analytical cross-sectional study involving patients from 2 dialysis units (1 referral hospital and 1 private dialysis unit) in Denpasar, Bali, Indonesia, from January 2020 to December 2021. We evaluated age, gender, duration of hemodialysis, vascular access, history of transfusion, history of surgery, diabetes mellitus, hepatitis B, human immunodeficiency virus (HIV) infection, and type of dialyzer as possible risk factors of hepatitis C seroconversion among hemodialysis patients. Results. A total of 338 hemodialysis patients were enrolled in this study. We found hepatitis C seroconversion in 94 patients (27.8%), all of which occurred after regular dialysis was started. Vascular access type (OR 42.07, 95% CI 5.757–307.472) and dialyzer reuse (OR 8.324, 95% CI 4.319–16.044) were showing a statistically significant association with hepatitis C seroconversion. A separate analysis on each dialysis unit found common evidence that the duration of dialysis was significantly associated with hepatitis C infection among hemodialysis patients. Conclusion. Hepatitis C seroconversion among dialysis patients remains high. Factors related to the dialysis procedure itself played a major role in transmitting the virus. |
| format | Article |
| id | doaj-art-8fa0f3c0c76947f3b19b2cd44991695f |
| institution | OA Journals |
| issn | 2090-3456 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-8fa0f3c0c76947f3b19b2cd44991695f2025-08-20T02:09:29ZengWileyInternational Journal of Hepatology2090-34562022-01-01202210.1155/2022/8109977Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk FactorsNi Wayan Wina Dharmesti0I Dewa Nyoman Wibawa1Yenny Kandarini2Division of Gastroentero-HepatologyDivision of Gastroentero-HepatologyDivision of NephrologyBackground/Aims. Hemodialysis patients have a higher risk of hepatitis C compared to the general population. The burden of hepatitis C infection among hemodialysis patients is substantial and was estimated to rise constantly. This study is aimed at determining the frequency of HCV seroconversion and associated risk factors among hemodialysis patients in our unit. Methods. An analytical cross-sectional study involving patients from 2 dialysis units (1 referral hospital and 1 private dialysis unit) in Denpasar, Bali, Indonesia, from January 2020 to December 2021. We evaluated age, gender, duration of hemodialysis, vascular access, history of transfusion, history of surgery, diabetes mellitus, hepatitis B, human immunodeficiency virus (HIV) infection, and type of dialyzer as possible risk factors of hepatitis C seroconversion among hemodialysis patients. Results. A total of 338 hemodialysis patients were enrolled in this study. We found hepatitis C seroconversion in 94 patients (27.8%), all of which occurred after regular dialysis was started. Vascular access type (OR 42.07, 95% CI 5.757–307.472) and dialyzer reuse (OR 8.324, 95% CI 4.319–16.044) were showing a statistically significant association with hepatitis C seroconversion. A separate analysis on each dialysis unit found common evidence that the duration of dialysis was significantly associated with hepatitis C infection among hemodialysis patients. Conclusion. Hepatitis C seroconversion among dialysis patients remains high. Factors related to the dialysis procedure itself played a major role in transmitting the virus.http://dx.doi.org/10.1155/2022/8109977 |
| spellingShingle | Ni Wayan Wina Dharmesti I Dewa Nyoman Wibawa Yenny Kandarini Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors International Journal of Hepatology |
| title | Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors |
| title_full | Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors |
| title_fullStr | Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors |
| title_full_unstemmed | Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors |
| title_short | Hepatitis C Seroconversion Remains High among Patients with Regular Hemodialysis: Study of Associated Risk Factors |
| title_sort | hepatitis c seroconversion remains high among patients with regular hemodialysis study of associated risk factors |
| url | http://dx.doi.org/10.1155/2022/8109977 |
| work_keys_str_mv | AT niwayanwinadharmesti hepatitiscseroconversionremainshighamongpatientswithregularhemodialysisstudyofassociatedriskfactors AT idewanyomanwibawa hepatitiscseroconversionremainshighamongpatientswithregularhemodialysisstudyofassociatedriskfactors AT yennykandarini hepatitiscseroconversionremainshighamongpatientswithregularhemodialysisstudyofassociatedriskfactors |