Causal Relationship Between Depression and Traumatic Brain Injury: A Two‐Sample Mendelian Randomization Analysis

Causal Relationship Between Depression and Traumatic Brain Injury: A Two‐Sample Mendelian Randomization Analysis

ABSTRACT Background Traumatic brain injury (TBI) and depression are major global health burdens, yet their bidirectional causal relationship remains unclear. Objective To explore the causal relationship between depression and TBI, and to clarify whether depression is one of the potential risk factor...

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Main Authors: Shiping Wang, Lei Pan, Binyang Wang, Qianwen Ruan, Ying Shi, Tong Sun, Xu Yang, Lei Zhang, Xiaohua Ke, Geng Li, Meihua Qiu, Chuanxiong Li
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Brain and Behavior
Subjects:
bidirectional MR
causal inference
depression
genetic instrumental variables
psychiatric comorbidity
TBI
Online Access:https://doi.org/10.1002/brb3.70669
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