Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients

Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients

BackgroundEssential thrombocythemia (ET) is one of the Philadelphia-negative (Ph−) classical myeloproliferative neoplasms (MPNs), characterized by increased megakaryocyte and platelet counts, as well as an increased risk of thrombo-hemorrhagic complications. The JAK2 V617F mutation is detected in 50...

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Bibliographic Details
Main Authors: Lin Luo, Xiaoyan Liu, Hui Shen, Hao Zhang, Yufeng Shang, Xian Zhang, Donglei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Hematology
Subjects:
essential thrombocythemia
myeloproliferative neoplasms
PTEN
STAT3
STAT5
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2025.1479185/full
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