Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design
The burden of HIV disease has shifted from traditional AIDS-defining illnesses to serious non-AIDS-defining comorbid conditions. Research aimed at improving HIV-related comorbid disease outcomes requires well-defined, verified clinical endpoints. We developed methods to ascertain and verify end-stag...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2015/923194 |
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| author | Mari M. Kitahata Daniel R. Drozd Heidi M. Crane Stephen E. Van Rompaey Keri N. Althoff Stephen J. Gange Marina B. Klein Gregory M. Lucas Alison G. Abraham Vincent Lo Re Justin McReynolds William B. Lober Adell Mendes Sharada P. Modur Yuezhou Jing Elizabeth J. Morton Margaret A. Griffith Aimee M. Freeman Richard D. Moore |
| author_facet | Mari M. Kitahata Daniel R. Drozd Heidi M. Crane Stephen E. Van Rompaey Keri N. Althoff Stephen J. Gange Marina B. Klein Gregory M. Lucas Alison G. Abraham Vincent Lo Re Justin McReynolds William B. Lober Adell Mendes Sharada P. Modur Yuezhou Jing Elizabeth J. Morton Margaret A. Griffith Aimee M. Freeman Richard D. Moore |
| author_sort | Mari M. Kitahata |
| collection | DOAJ |
| description | The burden of HIV disease has shifted from traditional AIDS-defining illnesses to serious non-AIDS-defining comorbid conditions. Research aimed at improving HIV-related comorbid disease outcomes requires well-defined, verified clinical endpoints. We developed methods to ascertain and verify end-stage renal disease (ESRD) and end-stage liver disease (ESLD) and validated screening algorithms within the largest HIV cohort collaboration in North America (NA-ACCORD). Individuals who screened positive among all participants in twelve cohorts enrolled between January 1996 and December 2009 underwent medical record review to verify incident ESRD or ESLD using standardized protocols. We randomly sampled 6% of contributing cohorts to determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ESLD and ESRD screening algorithms in a validation subcohort. Among 43,433 patients screened for ESRD, 822 screened positive of which 620 met clinical criteria for ESRD. The algorithm had 100% sensitivity, 99% specificity, 82% PPV, and 100% NPV for ESRD. Among 41,463 patients screened for ESLD, 2,024 screened positive of which 645 met diagnostic criteria for ESLD. The algorithm had 100% sensitivity, 95% specificity, 27% PPV, and 100% NPV for ESLD. Our methods proved robust for ascertainment of ESRD and ESLD in persons infected with HIV. |
| format | Article |
| id | doaj-art-8f9b0a165a9f470bb09448180532cd89 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-8f9b0a165a9f470bb09448180532cd892025-02-03T05:44:13ZengWileyAIDS Research and Treatment2090-12402090-12592015-01-01201510.1155/2015/923194923194Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and DesignMari M. Kitahata0Daniel R. Drozd1Heidi M. Crane2Stephen E. Van Rompaey3Keri N. Althoff4Stephen J. Gange5Marina B. Klein6Gregory M. Lucas7Alison G. Abraham8Vincent Lo Re9Justin McReynolds10William B. Lober11Adell Mendes12Sharada P. Modur13Yuezhou Jing14Elizabeth J. Morton15Margaret A. Griffith16Aimee M. Freeman17Richard D. Moore18Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USADivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USADivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USACenter for AIDS Research, University of Washington, Seattle, WA 98104, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USADivision of Infectious Diseases Chronic Viral Illness Service, Department of Medicine, McGill University, Montreal, QC, CanadaDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21287, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USACenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia VA Medical Center, Philadelphia, PA 19104, USAMedical Education and Biomedical Informatics, School of Medicine, University of Washington, Seattle, WA 98109, USAMedical Education and Biomedical Informatics, School of Medicine, University of Washington, Seattle, WA 98109, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USACenter for AIDS Research, University of Washington, Seattle, WA 98104, USACenter for AIDS Research, University of Washington, Seattle, WA 98104, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USABloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USAThe burden of HIV disease has shifted from traditional AIDS-defining illnesses to serious non-AIDS-defining comorbid conditions. Research aimed at improving HIV-related comorbid disease outcomes requires well-defined, verified clinical endpoints. We developed methods to ascertain and verify end-stage renal disease (ESRD) and end-stage liver disease (ESLD) and validated screening algorithms within the largest HIV cohort collaboration in North America (NA-ACCORD). Individuals who screened positive among all participants in twelve cohorts enrolled between January 1996 and December 2009 underwent medical record review to verify incident ESRD or ESLD using standardized protocols. We randomly sampled 6% of contributing cohorts to determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ESLD and ESRD screening algorithms in a validation subcohort. Among 43,433 patients screened for ESRD, 822 screened positive of which 620 met clinical criteria for ESRD. The algorithm had 100% sensitivity, 99% specificity, 82% PPV, and 100% NPV for ESRD. Among 41,463 patients screened for ESLD, 2,024 screened positive of which 645 met diagnostic criteria for ESLD. The algorithm had 100% sensitivity, 95% specificity, 27% PPV, and 100% NPV for ESLD. Our methods proved robust for ascertainment of ESRD and ESLD in persons infected with HIV.http://dx.doi.org/10.1155/2015/923194 |
| spellingShingle | Mari M. Kitahata Daniel R. Drozd Heidi M. Crane Stephen E. Van Rompaey Keri N. Althoff Stephen J. Gange Marina B. Klein Gregory M. Lucas Alison G. Abraham Vincent Lo Re Justin McReynolds William B. Lober Adell Mendes Sharada P. Modur Yuezhou Jing Elizabeth J. Morton Margaret A. Griffith Aimee M. Freeman Richard D. Moore Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design AIDS Research and Treatment |
| title | Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design |
| title_full | Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design |
| title_fullStr | Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design |
| title_full_unstemmed | Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design |
| title_short | Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design |
| title_sort | ascertainment and verification of end stage renal disease and end stage liver disease in the north american aids cohort collaboration on research and design |
| url | http://dx.doi.org/10.1155/2015/923194 |
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