COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE
Aim. To evaluate clinical and cost effectiveness of different reperfusion strategies in myocardial infarction with ST segment elevation (STEMI), including pre-hospital thrombolysis with tenecteplase. Material and methods. Methods of cost-effectiveness analysis and economic modeling were used to cal...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/742 |
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| author | V. V. Omel'yanovskiy E. V. Derkach P. M. Khaylov S. N. Tereshchenko |
| author_facet | V. V. Omel'yanovskiy E. V. Derkach P. M. Khaylov S. N. Tereshchenko |
| author_sort | V. V. Omel'yanovskiy |
| collection | DOAJ |
| description | Aim. To evaluate clinical and cost effectiveness of different reperfusion strategies in myocardial infarction with ST segment elevation (STEMI), including pre-hospital thrombolysis with tenecteplase. Material and methods. Methods of cost-effectiveness analysis and economic modeling were used to calculate the costs of reperfusion in STEMI, expected number of life gains, the cost of life gains depending on reperfusion strategy (no reperfusion, percutaneous coronary intervention (PCI), prehospital thrombolysis, hospital thrombolysis). Results. In accordance to analysis results and from economic point of view, the most effective strategy is primary PCI in patients within "therapeutic window" and pre-hospital thrombolysis in the remaining patients with STEMI. More complex strategy of patients flow control with patient division into groups of primary PCI, pre-hospital thrombolysis and hospital thrombolysis lead to decrease in reperfusion costs efficacy. Conclusion. The reperfusion model with primary PCI in the first 120 minutes after STEMI symptoms onset, and pre-hospital thrombolysis with bolus thrombolytic administration, when PCI is not possible in this period, is the most effective economically and in respect on mortality reduction in patients with STEMI. |
| format | Article |
| id | doaj-art-8f97cec9039d4447ab280ed8f38c8bca |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-8f97cec9039d4447ab280ed8f38c8bca2025-08-23T10:00:22ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-017214515010.20996/1819-6446-2011-7-2-145-150741COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASEV. V. Omel'yanovskiy0E. V. Derkach1P. M. Khaylov2S. N. Tereshchenko3Research Institute of Clinical and Economic Expertise and Pharmacoeconomics, Russian State Medical UniversityResearch Institute of Clinical and Economic Expertise and Pharmacoeconomics, Russian State Medical UniversityResearch Institute of Clinical and Economic Expertise and Pharmacoeconomics, Russian State Medical UniversityMoscow State University of Medicine and DentistryAim. To evaluate clinical and cost effectiveness of different reperfusion strategies in myocardial infarction with ST segment elevation (STEMI), including pre-hospital thrombolysis with tenecteplase. Material and methods. Methods of cost-effectiveness analysis and economic modeling were used to calculate the costs of reperfusion in STEMI, expected number of life gains, the cost of life gains depending on reperfusion strategy (no reperfusion, percutaneous coronary intervention (PCI), prehospital thrombolysis, hospital thrombolysis). Results. In accordance to analysis results and from economic point of view, the most effective strategy is primary PCI in patients within "therapeutic window" and pre-hospital thrombolysis in the remaining patients with STEMI. More complex strategy of patients flow control with patient division into groups of primary PCI, pre-hospital thrombolysis and hospital thrombolysis lead to decrease in reperfusion costs efficacy. Conclusion. The reperfusion model with primary PCI in the first 120 minutes after STEMI symptoms onset, and pre-hospital thrombolysis with bolus thrombolytic administration, when PCI is not possible in this period, is the most effective economically and in respect on mortality reduction in patients with STEMI.https://www.rpcardio.online/jour/article/view/742myocardial infarction with st segment elevationreperfusionthrombolysistenecteplasepercutaneous coronary intervention |
| spellingShingle | V. V. Omel'yanovskiy E. V. Derkach P. M. Khaylov S. N. Tereshchenko COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE Рациональная фармакотерапия в кардиологии myocardial infarction with st segment elevation reperfusion thrombolysis tenecteplase percutaneous coronary intervention |
| title | COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE |
| title_full | COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE |
| title_fullStr | COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE |
| title_full_unstemmed | COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE |
| title_short | COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE |
| title_sort | cost effectiveness evaluation of prehospital thrombolysis with tenecteplase |
| topic | myocardial infarction with st segment elevation reperfusion thrombolysis tenecteplase percutaneous coronary intervention |
| url | https://www.rpcardio.online/jour/article/view/742 |
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