ADCC: the rock band led by therapeutic antibodies, tumor and immune cells

ADCC: the rock band led by therapeutic antibodies, tumor and immune cells

Antibody-dependent cellular cytotoxicity (ADCC) is a critical mechanism by which therapeutic antibodies leverage the immune system to target and eliminate cancer cells. The key agents of ADCC are natural killer (NK) cells, specifically targeting antibody-covered cancer cells through the CD16 recepto...

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Bibliographic Details
Main Authors:	Roos Vincken, Uxue Armendáriz-Martínez, Ana Ruiz-Sáenz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Immunology
Subjects:	antibody-dependent cellular cytotoxicity cancer immune co-cultures natural killer cells ADCC readouts therapeutic antibodies immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1548292/full
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