Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis
We present a case of a 27-year-old man with recurrent episodes of angioedema since he was 19, who responded well to treatment with medical grade cannabis. Initially, he responded to steroids and antihistam...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2015/780824 |
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| _version_ | 1832549868111921152 |
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| author | Amit Frenkel Aviel Roy-Shapira Brotfain Evgeni Koyfman Leonid Abraham Borer Moti Klein |
| author_facet | Amit Frenkel Aviel Roy-Shapira Brotfain Evgeni Koyfman Leonid Abraham Borer Moti Klein |
| author_sort | Amit Frenkel |
| collection | DOAJ |
| description | We present a case of
a 27-year-old man with recurrent episodes of
angioedema since he was 19, who responded well
to treatment with medical grade cannabis.
Initially, he responded to steroids and
antihistamines, but several attempts to withdraw
treatment resulted in recurrence. In the last
few months before prescribing cannabis, the
frequency and severity of the attacks worsened
and included several presyncope events,
associated with scrotal and neck swelling. No
predisposing factors were identified, and
extensive workup was negative. The patient
reported that he was periodically using cannabis
socially and that during these periods he was
free of attacks. Recent data suggest that
cannabis derivatives are involved in the control
of mast cell activation. Consequently, we
decided to try a course of inhaled cannabis as
modulators of immune cell functions. The use of
inhaled cannabis resulted in a complete
response, and he has been free of symptoms for 2
years. An attempt to withhold the inhaled
cannabis led to a recurrent attack within a
week, and resuming cannabis maintained the
remission, suggesting a cause and effect
relationship. |
| format | Article |
| id | doaj-art-8f9131ba96ac4cd19192051942dcd7a8 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-8f9131ba96ac4cd19192051942dcd7a82025-02-03T06:08:25ZengWileyCase Reports in Immunology2090-66092090-66172015-01-01201510.1155/2015/780824780824Life Threatening Idiopathic Recurrent Angioedema Responding to CannabisAmit Frenkel0Aviel Roy-Shapira1Brotfain Evgeni2Koyfman Leonid3Abraham Borer4Moti Klein5General Intensive Care Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Beersheba, IsraelGeneral Intensive Care Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Beersheba, IsraelGeneral Intensive Care Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Beersheba, IsraelGeneral Intensive Care Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Beersheba, IsraelInfection Control and Hospital Epidemiology Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Beersheba, IsraelGeneral Intensive Care Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Beersheba, IsraelWe present a case of a 27-year-old man with recurrent episodes of angioedema since he was 19, who responded well to treatment with medical grade cannabis. Initially, he responded to steroids and antihistamines, but several attempts to withdraw treatment resulted in recurrence. In the last few months before prescribing cannabis, the frequency and severity of the attacks worsened and included several presyncope events, associated with scrotal and neck swelling. No predisposing factors were identified, and extensive workup was negative. The patient reported that he was periodically using cannabis socially and that during these periods he was free of attacks. Recent data suggest that cannabis derivatives are involved in the control of mast cell activation. Consequently, we decided to try a course of inhaled cannabis as modulators of immune cell functions. The use of inhaled cannabis resulted in a complete response, and he has been free of symptoms for 2 years. An attempt to withhold the inhaled cannabis led to a recurrent attack within a week, and resuming cannabis maintained the remission, suggesting a cause and effect relationship.http://dx.doi.org/10.1155/2015/780824 |
| spellingShingle | Amit Frenkel Aviel Roy-Shapira Brotfain Evgeni Koyfman Leonid Abraham Borer Moti Klein Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis Case Reports in Immunology |
| title | Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis |
| title_full | Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis |
| title_fullStr | Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis |
| title_full_unstemmed | Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis |
| title_short | Life Threatening Idiopathic Recurrent Angioedema Responding to Cannabis |
| title_sort | life threatening idiopathic recurrent angioedema responding to cannabis |
| url | http://dx.doi.org/10.1155/2015/780824 |
| work_keys_str_mv | AT amitfrenkel lifethreateningidiopathicrecurrentangioedemarespondingtocannabis AT avielroyshapira lifethreateningidiopathicrecurrentangioedemarespondingtocannabis AT brotfainevgeni lifethreateningidiopathicrecurrentangioedemarespondingtocannabis AT koyfmanleonid lifethreateningidiopathicrecurrentangioedemarespondingtocannabis AT abrahamborer lifethreateningidiopathicrecurrentangioedemarespondingtocannabis AT motiklein lifethreateningidiopathicrecurrentangioedemarespondingtocannabis |