Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions
Giant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare but serious risk of delayed post-operative rupture...
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MDPI AG
2025-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/3/305 |
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| author | Pablo Jeken-Rico Yves Chau Aurèle Goetz Jacques Sedat Elie Hachem |
| author_facet | Pablo Jeken-Rico Yves Chau Aurèle Goetz Jacques Sedat Elie Hachem |
| author_sort | Pablo Jeken-Rico |
| collection | DOAJ |
| description | Giant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare but serious risk of delayed post-operative rupture. The underlying mechanisms of these ruptures remain unknown, due to the biomechanical complexity of giant aneurysms and challenges in replicating in vivo hemodynamic conditions within numerical simulation frameworks. This study presents a novel fluid–structure interaction simulation of a giant intracranial aneurysm treated with a flow diverter, based on high-resolution rotational angiography imaging. The resulting hemodynamics are compared to three established delayed-rupture hypotheses involving pressure rises, chaotic flow and autolysis. When considering wall compliance, the analysis reveals a consistent phase shift, dampening in pressure cycles, and an increased aneurysmal flow. These findings highlight the need for revisiting existing hypotheses and provide a foundation for advancing both computational modelling and clinical management strategies for giant intracranial aneurysms. |
| format | Article |
| id | doaj-art-8f9002b4c7ec43059f285d47d02ed79a |
| institution | DOAJ |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-8f9002b4c7ec43059f285d47d02ed79a2025-08-20T02:42:45ZengMDPI AGBioengineering2306-53542025-03-0112330510.3390/bioengineering12030305Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure InteractionsPablo Jeken-Rico0Yves Chau1Aurèle Goetz2Jacques Sedat3Elie Hachem4Mines Paris, Université PSL, Centre de Mise en Forme des Matériaux (CEMEF), UMR7635 CNRS, 06904 Sophia Antipolis, FranceInterventional Neuroradiology Department, Nice University Hospital, 06100 Nice, FranceMines Paris, Université PSL, Centre de Mise en Forme des Matériaux (CEMEF), UMR7635 CNRS, 06904 Sophia Antipolis, FranceInterventional Neuroradiology Department, Nice University Hospital, 06100 Nice, FranceMines Paris, Université PSL, Centre de Mise en Forme des Matériaux (CEMEF), UMR7635 CNRS, 06904 Sophia Antipolis, FranceGiant intracranial aneurysms are frequently treated shortly after discovery due to their increased risk of rupture and commonly symptomatic nature. Among available treatments, flow diverters are often the sole viable option, though they carry a rare but serious risk of delayed post-operative rupture. The underlying mechanisms of these ruptures remain unknown, due to the biomechanical complexity of giant aneurysms and challenges in replicating in vivo hemodynamic conditions within numerical simulation frameworks. This study presents a novel fluid–structure interaction simulation of a giant intracranial aneurysm treated with a flow diverter, based on high-resolution rotational angiography imaging. The resulting hemodynamics are compared to three established delayed-rupture hypotheses involving pressure rises, chaotic flow and autolysis. When considering wall compliance, the analysis reveals a consistent phase shift, dampening in pressure cycles, and an increased aneurysmal flow. These findings highlight the need for revisiting existing hypotheses and provide a foundation for advancing both computational modelling and clinical management strategies for giant intracranial aneurysms.https://www.mdpi.com/2306-5354/12/3/305intracranial aneurysmsfluid–structure interactiondelayed ruptureflow diverter |
| spellingShingle | Pablo Jeken-Rico Yves Chau Aurèle Goetz Jacques Sedat Elie Hachem Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions Bioengineering intracranial aneurysms fluid–structure interaction delayed rupture flow diverter |
| title | Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions |
| title_full | Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions |
| title_fullStr | Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions |
| title_full_unstemmed | Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions |
| title_short | Investigating Delayed Rupture of Flow Diverter-Treated Giant Aneurysm Using Simulated Fluid–Structure Interactions |
| title_sort | investigating delayed rupture of flow diverter treated giant aneurysm using simulated fluid structure interactions |
| topic | intracranial aneurysms fluid–structure interaction delayed rupture flow diverter |
| url | https://www.mdpi.com/2306-5354/12/3/305 |
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