Midazolam for treatment of refractory neonatal seizures: a case report
Midazolam is a short-acting water soluble benzodiazepine that has been used with an increasing frequency in the last years. Although there are reports on its use in status epilepticus, there is none in the neonatal period. A pre-term (35 w) AGA newborn infant with a severe hypoxic-ischemic encephalo...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
1994-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200019&lng=en&tlng=en |
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| _version_ | 1849695127534043136 |
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| author | José Luiz Dias Gherpelli Francisco José C. Luccas Israel Roitman Eduardo Juan Troster |
| author_facet | José Luiz Dias Gherpelli Francisco José C. Luccas Israel Roitman Eduardo Juan Troster |
| author_sort | José Luiz Dias Gherpelli |
| collection | DOAJ |
| description | Midazolam is a short-acting water soluble benzodiazepine that has been used with an increasing frequency in the last years. Although there are reports on its use in status epilepticus, there is none in the neonatal period. A pre-term (35 w) AGA newborn infant with a severe hypoxic-ischemic encephalopathy secondary to grade ED hyaline membrane disease developed status epilepticus in the first 6 hours of life and was successfully treated with midazolam after phenobarbital and phenytoin failed to achieve seizure control. Dosage schedule was 0.2 mg/kg IV, followed by continuous infusion of 0.025 mg/kg/h. Midazolam is an effective drug for neonatal status epilepticus and more experience should accumulate before it can be routinely employed in the neonatal period. This case shows that it is a possible option before using more dangerous drugs, such as thionembutal. |
| format | Article |
| id | doaj-art-8f8bee6b760b40fda84b29e962c948ea |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 1994-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-8f8bee6b760b40fda84b29e962c948ea2025-08-20T03:19:52ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42271994-06-0152226026210.1590/S0004-282X1994000200019S0004-282X1994000200019Midazolam for treatment of refractory neonatal seizures: a case reportJosé Luiz Dias Gherpelli0Francisco José C. Luccas1Israel Roitman2Eduardo Juan Troster3Hospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinMidazolam is a short-acting water soluble benzodiazepine that has been used with an increasing frequency in the last years. Although there are reports on its use in status epilepticus, there is none in the neonatal period. A pre-term (35 w) AGA newborn infant with a severe hypoxic-ischemic encephalopathy secondary to grade ED hyaline membrane disease developed status epilepticus in the first 6 hours of life and was successfully treated with midazolam after phenobarbital and phenytoin failed to achieve seizure control. Dosage schedule was 0.2 mg/kg IV, followed by continuous infusion of 0.025 mg/kg/h. Midazolam is an effective drug for neonatal status epilepticus and more experience should accumulate before it can be routinely employed in the neonatal period. This case shows that it is a possible option before using more dangerous drugs, such as thionembutal.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200019&lng=en&tlng=enstatus epilepticusconvulsão neonatalrecém-nascido de alto riscoencefalopatia neonatal hipóxico-isquêmica |
| spellingShingle | José Luiz Dias Gherpelli Francisco José C. Luccas Israel Roitman Eduardo Juan Troster Midazolam for treatment of refractory neonatal seizures: a case report Arquivos de Neuro-Psiquiatria status epilepticus convulsão neonatal recém-nascido de alto risco encefalopatia neonatal hipóxico-isquêmica |
| title | Midazolam for treatment of refractory neonatal seizures: a case report |
| title_full | Midazolam for treatment of refractory neonatal seizures: a case report |
| title_fullStr | Midazolam for treatment of refractory neonatal seizures: a case report |
| title_full_unstemmed | Midazolam for treatment of refractory neonatal seizures: a case report |
| title_short | Midazolam for treatment of refractory neonatal seizures: a case report |
| title_sort | midazolam for treatment of refractory neonatal seizures a case report |
| topic | status epilepticus convulsão neonatal recém-nascido de alto risco encefalopatia neonatal hipóxico-isquêmica |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000200019&lng=en&tlng=en |
| work_keys_str_mv | AT joseluizdiasgherpelli midazolamfortreatmentofrefractoryneonatalseizuresacasereport AT franciscojosecluccas midazolamfortreatmentofrefractoryneonatalseizuresacasereport AT israelroitman midazolamfortreatmentofrefractoryneonatalseizuresacasereport AT eduardojuantroster midazolamfortreatmentofrefractoryneonatalseizuresacasereport |