Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer
<b>Background/Objectives</b>: We aimed to evaluate the effectiveness of a 0.1% cyclosporin A cationic emulsion (CsA-CE) for dry eye disease (DED) post-cataract surgery using the DED index measured with a Placido tear film analyzer. <b>Methods</b>: We retrospectively reviewed...
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MDPI AG
2025-04-01
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| Series: | Diagnostics |
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| author | Song-A Che Sang Beom Han Yongwoo Lee |
| author_facet | Song-A Che Sang Beom Han Yongwoo Lee |
| author_sort | Song-A Che |
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| description | <b>Background/Objectives</b>: We aimed to evaluate the effectiveness of a 0.1% cyclosporin A cationic emulsion (CsA-CE) for dry eye disease (DED) post-cataract surgery using the DED index measured with a Placido tear film analyzer. <b>Methods</b>: We retrospectively reviewed the medical records of patients who underwent simple cataract surgery. All patients used 0.5% moxifloxacin and 1% prednisolone acetate eye drops four times daily postoperatively. They were divided into the CsA-CE and control groups based on whether they had used CsA-CE 1 week after surgery. Subjective and objective assessments were performed at the baseline and 1 month postoperation. The non-invasive tear meniscus height, non-invasive tear break-up time, conjunctival redness, meibomian gland morphology, and lipid layer thickness were assessed using the Keratograph 5M (Oculus). <b>Results</b>: No differences were observed in the preoperative dry eye parameters between the groups. The ocular surface disease index decreased from 19.26 to 14.58 (<i>p</i> = 0.046) at 1 month postoperation for the CsA-CE group, and the average non-invasive tear break-up time significantly increased from 10.97 to 13.00 s (<i>p</i> = 0.002). No such differences were observed for the control group. Nasal bulbar conjunctival hyperemia increased (<i>p</i> < 0.001) for the control group. Nasal limbal hyperemia and overall limbal hyperemia increased for both groups (CsA-CE, <i>p</i> = 0.005, 0.017; control, <i>p</i> = 0.001, 0.012). The lipid layer thickness increased from 70.29 to 86.41 nm for the CsA-CE group (<i>p</i> < 0.001), whereas no significant change was noted for the control group. <b>Conclusions</b>: CsA-CE (0.1%) is effective for treating DED after cataract surgery and improves the tear lipid layer. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-8f8837f8a4ca4c70ae61bc4ca1e081432025-08-20T02:17:20ZengMDPI AGDiagnostics2075-44182025-04-0115898110.3390/diagnostics15080981Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film AnalyzerSong-A Che0Sang Beom Han1Yongwoo Lee2Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24289, Republic of KoreaSaevit Eye Hospital, Goyang 10447, Republic of KoreaDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24289, Republic of Korea<b>Background/Objectives</b>: We aimed to evaluate the effectiveness of a 0.1% cyclosporin A cationic emulsion (CsA-CE) for dry eye disease (DED) post-cataract surgery using the DED index measured with a Placido tear film analyzer. <b>Methods</b>: We retrospectively reviewed the medical records of patients who underwent simple cataract surgery. All patients used 0.5% moxifloxacin and 1% prednisolone acetate eye drops four times daily postoperatively. They were divided into the CsA-CE and control groups based on whether they had used CsA-CE 1 week after surgery. Subjective and objective assessments were performed at the baseline and 1 month postoperation. The non-invasive tear meniscus height, non-invasive tear break-up time, conjunctival redness, meibomian gland morphology, and lipid layer thickness were assessed using the Keratograph 5M (Oculus). <b>Results</b>: No differences were observed in the preoperative dry eye parameters between the groups. The ocular surface disease index decreased from 19.26 to 14.58 (<i>p</i> = 0.046) at 1 month postoperation for the CsA-CE group, and the average non-invasive tear break-up time significantly increased from 10.97 to 13.00 s (<i>p</i> = 0.002). No such differences were observed for the control group. Nasal bulbar conjunctival hyperemia increased (<i>p</i> < 0.001) for the control group. Nasal limbal hyperemia and overall limbal hyperemia increased for both groups (CsA-CE, <i>p</i> = 0.005, 0.017; control, <i>p</i> = 0.001, 0.012). The lipid layer thickness increased from 70.29 to 86.41 nm for the CsA-CE group (<i>p</i> < 0.001), whereas no significant change was noted for the control group. <b>Conclusions</b>: CsA-CE (0.1%) is effective for treating DED after cataract surgery and improves the tear lipid layer.https://www.mdpi.com/2075-4418/15/8/981dry eye diseasecyclosporinecationic emulsioncataractcyclosporine 0.1%, Placido tear film analyzer |
| spellingShingle | Song-A Che Sang Beom Han Yongwoo Lee Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer Diagnostics dry eye disease cyclosporine cationic emulsion cataract cyclosporine 0.1%, Placido tear film analyzer |
| title | Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer |
| title_full | Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer |
| title_fullStr | Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer |
| title_full_unstemmed | Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer |
| title_short | Effectiveness of 0.1% Cyclosporine a Cationic Emulsion for Treating Dry Eye Disease After Cataract Surgery Analyzed Using a Placido Tear Film Analyzer |
| title_sort | effectiveness of 0 1 cyclosporine a cationic emulsion for treating dry eye disease after cataract surgery analyzed using a placido tear film analyzer |
| topic | dry eye disease cyclosporine cationic emulsion cataract cyclosporine 0.1%, Placido tear film analyzer |
| url | https://www.mdpi.com/2075-4418/15/8/981 |
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