5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation.

5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation.

The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is critically discussed. A possible reason for reduced osteogenic potential may be an age-related deterioration of the Ad-MSCs. In long term in vitro culture, epigenomic changes in DNA methylation are kno...

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Main Authors: Xueying Yan, Sabrina Ehnert, Mihaela Culmes, Anastasia Bachmann, Claudine Seeliger, Lilianna Schyschka, Zhiyong Wang, Afshin Rahmanian-Schwarz, Ulrich Stöckle, Paul A De Sousa, Jaroslav Pelisek, Andreas K Nussler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090846&type=printable
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