Training/detraining-induced gender specific functional adaptations of isolated rat heart
Background/Aim. Mechanisms responsible for the beneficial effects of aerobic exercise training on cardiovascular function are well known, but detraining effects on myocardial parameters have not been adequately elucidated. Therefore, the study aimed to determine the occurrence and speed of cardiac a...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2021-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000027D.pdf |
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| author | Dragojlović-Ružičić Radica Radovanović Dragan Milanović Zvezdan Petković Anica Jeremić Jovana Nikolić-Тurnić Tamara Milosavljević Isidora Srejović Ivan Živković Vladimir Krivokuća Živko Jakovljević Vladimir Đorđević Dušica |
| author_facet | Dragojlović-Ružičić Radica Radovanović Dragan Milanović Zvezdan Petković Anica Jeremić Jovana Nikolić-Тurnić Tamara Milosavljević Isidora Srejović Ivan Živković Vladimir Krivokuća Živko Jakovljević Vladimir Đorđević Dušica |
| author_sort | Dragojlović-Ružičić Radica |
| collection | DOAJ |
| description | Background/Aim. Mechanisms responsible for the beneficial effects of aerobic exercise training on cardiovascular function are well known, but detraining effects on myocardial parameters have not been adequately elucidated. Therefore, the study aimed to determine the occurrence and speed of cardiac adaptation reversibility after the cessation of aerobic exercise and to reveal gender differences in achieved effects of training/detraining. Methods. Fe-male and male Wistar albino rats were divided into the following groups: control, trained, and two detrained groups. Hearts were perfused according to the Langendorff technique and the following cardiodynamic parameters were determined: the maximum and minimum rate of pressure development in the left ventricle (dp/dt max and dp/dt min, respectively), systolic and diastolic left ventricular pressure (SLVP and DLVP, respectively), heart rate (HR), and coronary flow. Results. Training significantly reduced values of dp/dt max, dp/dt min, and SLVP in males and females, and coronary flow in males. Detraining caused a reversion of those changes, which was gender-specific. In females, levels of SLVP were higher after 4 weeks of detraining compred to training, and after 2 weeks of detraining. Values of SLVP were lower in both detraining periods compared to training in males. Males had higher coronary flow after 2 weeks of detraining. Simultaneously, coronary flow was reduced in the 4th week of detraining in females. Conclusion. By using a model of the isolated rat heart, the present study confirmed the existence of training-induced changes in cardiac function. Cessation of training was followed by the loss of those adaptations, faster in males than females. |
| format | Article |
| id | doaj-art-8f84c8443de545b59f41fefec78ac600 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-8f84c8443de545b59f41fefec78ac6002025-08-20T01:58:38ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202021-01-0178111146115410.2298/VSP191127027D0042-84502000027DTraining/detraining-induced gender specific functional adaptations of isolated rat heartDragojlović-Ružičić Radica0Radovanović Dragan1Milanović Zvezdan2Petković Anica3https://orcid.org/0000-0003-3048-4264Jeremić Jovana4https://orcid.org/0000-0002-8084-3264Nikolić-Тurnić Tamara5Milosavljević Isidora6Srejović Ivan7https://orcid.org/0000-0002-3835-1856Živković Vladimir8Krivokuća Živko9Jakovljević Vladimir10Đorđević Dušica11University of Belgrade, High Medical College of Professional Studies “Milutin Milanković”, Belgrade, SerbiaUniversity of Niš, Faculty of Sport and Physical Education, Department of Physiology, Niš, SerbiaUniversity of Priština/Kosovska Mitrovica, Faculty of Medical Sciences, Department of Physiology, Kosovska Mitrovica, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences,Department of Physiology, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences,Department of Physiology, Kragujevac, SerbiaGarrison Ambulance Požega, Požega, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Physiology, Kragujevac, Serbia + First Moscow State Medical University I.M. Sechenov, Department of Human Pathology, Moscow, RussiaUniversity of Kragujevac, Faculty of Medical Sciences,Department of Physiology, Kragujevac, SerbiaBackground/Aim. Mechanisms responsible for the beneficial effects of aerobic exercise training on cardiovascular function are well known, but detraining effects on myocardial parameters have not been adequately elucidated. Therefore, the study aimed to determine the occurrence and speed of cardiac adaptation reversibility after the cessation of aerobic exercise and to reveal gender differences in achieved effects of training/detraining. Methods. Fe-male and male Wistar albino rats were divided into the following groups: control, trained, and two detrained groups. Hearts were perfused according to the Langendorff technique and the following cardiodynamic parameters were determined: the maximum and minimum rate of pressure development in the left ventricle (dp/dt max and dp/dt min, respectively), systolic and diastolic left ventricular pressure (SLVP and DLVP, respectively), heart rate (HR), and coronary flow. Results. Training significantly reduced values of dp/dt max, dp/dt min, and SLVP in males and females, and coronary flow in males. Detraining caused a reversion of those changes, which was gender-specific. In females, levels of SLVP were higher after 4 weeks of detraining compred to training, and after 2 weeks of detraining. Values of SLVP were lower in both detraining periods compared to training in males. Males had higher coronary flow after 2 weeks of detraining. Simultaneously, coronary flow was reduced in the 4th week of detraining in females. Conclusion. By using a model of the isolated rat heart, the present study confirmed the existence of training-induced changes in cardiac function. Cessation of training was followed by the loss of those adaptations, faster in males than females.http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000027D.pdfadaptation, physiologicalexerciseratsheartgender |
| spellingShingle | Dragojlović-Ružičić Radica Radovanović Dragan Milanović Zvezdan Petković Anica Jeremić Jovana Nikolić-Тurnić Tamara Milosavljević Isidora Srejović Ivan Živković Vladimir Krivokuća Živko Jakovljević Vladimir Đorđević Dušica Training/detraining-induced gender specific functional adaptations of isolated rat heart Vojnosanitetski Pregled adaptation, physiological exercise rats heart gender |
| title | Training/detraining-induced gender specific functional adaptations of isolated rat heart |
| title_full | Training/detraining-induced gender specific functional adaptations of isolated rat heart |
| title_fullStr | Training/detraining-induced gender specific functional adaptations of isolated rat heart |
| title_full_unstemmed | Training/detraining-induced gender specific functional adaptations of isolated rat heart |
| title_short | Training/detraining-induced gender specific functional adaptations of isolated rat heart |
| title_sort | training detraining induced gender specific functional adaptations of isolated rat heart |
| topic | adaptation, physiological exercise rats heart gender |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000027D.pdf |
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