Interpretable single-cell factor decomposition using sciRED

Abstract Single-cell RNA sequencing maps gene expression heterogeneity within a tissue. However, identifying biological signals in this data is challenging due to confounding technical factors, sparsity, and high dimensionality. Data factorization methods address this by separating and identifying s...

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Bibliographic Details
Main Authors: Delaram Pouyabahar, Tallulah Andrews, Gary D. Bader
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57157-2
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