Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report

Plantar warts are common skin neoplasms caused by human papillomavirus (HPV) infection. Patients with immunocompromised conditions often have a higher prevalence of HPV infection-induced skin warts, with recalcitrant nature to various options of treatment. Here, we diagnosed a case of multiple and c...

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Main Authors: Fangfang Wang, Lingzhi Li, Suling Xu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100025001127
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author Fangfang Wang
Lingzhi Li
Suling Xu
author_facet Fangfang Wang
Lingzhi Li
Suling Xu
author_sort Fangfang Wang
collection DOAJ
description Plantar warts are common skin neoplasms caused by human papillomavirus (HPV) infection. Patients with immunocompromised conditions often have a higher prevalence of HPV infection-induced skin warts, with recalcitrant nature to various options of treatment. Here, we diagnosed a case of multiple and coalesced plantar warts complicated by Systemic Lupus Erythematosus (SLE) which persisted for years and was refractory to conventional treatment. Following superficial shaving to remove the thickened corneum, we initiated 5-aminolevulinic acid - photodynamic therapy (ALA-PDT). After four rounds of the treatments within two months, the lesions were completely cleared with no recurrence in one year of follow-up.
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spelling doaj-art-8f737f9864df47de921b02cc1897e1dd2025-08-20T02:19:47ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-06-015310458310.1016/j.pdpdt.2025.104583Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case reportFangfang Wang0Lingzhi Li1Suling Xu2Department of Dermatology, the First Affiliated Hospital of Ningbo University, Ningbo university, Ningbo 315010, PR China; Health science center, Ningbo university, Ningbo 315211, PR ChinaDepartment of Dermatology, the First Affiliated Hospital of Ningbo University, Ningbo university, Ningbo 315010, PR ChinaDepartment of Dermatology, the First Affiliated Hospital of Ningbo University, Ningbo university, Ningbo 315010, PR China; Health science center, Ningbo university, Ningbo 315211, PR China; Correspondence author at: Department of Dermatology, the First Affiliated Hospital of Ningbo University, No.59 Liuting Road, Haishu District, Ningbo 315010, PR China.Plantar warts are common skin neoplasms caused by human papillomavirus (HPV) infection. Patients with immunocompromised conditions often have a higher prevalence of HPV infection-induced skin warts, with recalcitrant nature to various options of treatment. Here, we diagnosed a case of multiple and coalesced plantar warts complicated by Systemic Lupus Erythematosus (SLE) which persisted for years and was refractory to conventional treatment. Following superficial shaving to remove the thickened corneum, we initiated 5-aminolevulinic acid - photodynamic therapy (ALA-PDT). After four rounds of the treatments within two months, the lesions were completely cleared with no recurrence in one year of follow-up.http://www.sciencedirect.com/science/article/pii/S1572100025001127Systemic lupus erythematosusMultiplePlantar wartsHPVALA-PDTPhotodynamic therapy
spellingShingle Fangfang Wang
Lingzhi Li
Suling Xu
Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report
Photodiagnosis and Photodynamic Therapy
Systemic lupus erythematosus
Multiple
Plantar warts
HPV
ALA-PDT
Photodynamic therapy
title Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report
title_full Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report
title_fullStr Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report
title_full_unstemmed Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report
title_short Successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ALA-PDT, a case report
title_sort successful treatment of multiple plantar warts complicated by systemic lupus erythematosus with ala pdt a case report
topic Systemic lupus erythematosus
Multiple
Plantar warts
HPV
ALA-PDT
Photodynamic therapy
url http://www.sciencedirect.com/science/article/pii/S1572100025001127
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AT lingzhili successfultreatmentofmultipleplantarwartscomplicatedbysystemiclupuserythematosuswithalapdtacasereport
AT sulingxu successfultreatmentofmultipleplantarwartscomplicatedbysystemiclupuserythematosuswithalapdtacasereport